Formulation of sustained release lipid-based matrix system for vaginal delivery using the twin-screw hot-melt extrusion method

Valentyn Mohylyuk; Thomas Hutton; Suha Dadou; Yiwei Tian; Shu Li; David Jones; Gavin Andrews

Formulation of sustained release lipid-based matrix system for vaginal delivery using the twin-screw hot-melt extrusion method

Valentyn Mohylyuk, Thomas Hutton, Suha Dadou, Yiwei Tian, Shu Li, David Jones, Gavin Andrews

School of Pharmacy

Research output: Contribution to conference › Poster › peer-review

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Abstract

The development of sustained-release formulations for vaginal delivery of certain drugs has a big potential toward the increase of the treatment efficiency and patient compliance. One of the possible strategies to formulate sustained release dosage form for vaginal delivery is the incorporation of sustained-release microparticles into the bio-adhesive gel. Objectives of this study were to assess the possibility to formulate matrix system microparticles for vaginal delivery using lipid-based excipient SyncrowaxTM HGLC and optionally Gelucire® 50/13 (G-50/13), Avicel® PH-101 (MCC) or hypromellose type K100M excipients. As model drugs for this purpose were chosen antiretroviral zidovudine (known as azidothymidine; AZT) and antimicrobial metronidazole (MTZ).

Original language	English
Publication status	Published - 11 May 2021
Event	12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology - Vienna, Austria Duration: 11 May 2021 → 14 May 2021

Conference

Conference	12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology
Country/Territory	Austria
City	Vienna
Period	11/05/2021 → 14/05/2021

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Formulation of sustained release lipid-based matrix system for vaginal delivery using the twin-screw hot-melt extrusion method
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title = "Formulation of sustained release lipid-based matrix system for vaginal delivery using the twin-screw hot-melt extrusion method",

abstract = "The development of sustained-release formulations for vaginal delivery of certain drugs has a big potential toward the increase of the treatment efficiency and patient compliance. One of the possible strategies to formulate sustained release dosage form for vaginal delivery is the incorporation of sustained-release microparticles into the bio-adhesive gel. Objectives of this study were to assess the possibility to formulate matrix system microparticles for vaginal delivery using lipid-based excipient SyncrowaxTM HGLC and optionally Gelucire{\textregistered} 50/13 (G-50/13), Avicel{\textregistered} PH-101 (MCC) or hypromellose type K100M excipients. As model drugs for this purpose were chosen antiretroviral zidovudine (known as azidothymidine; AZT) and antimicrobial metronidazole (MTZ).",

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Formulation of sustained release lipid-based matrix system for vaginal delivery using the twin-screw hot-melt extrusion method. / Mohylyuk, Valentyn; Hutton, Thomas; Dadou, Suha et al.
2021. Poster session presented at 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Vienna, Austria.

Research output: Contribution to conference › Poster › peer-review

TY - CONF

T1 - Formulation of sustained release lipid-based matrix system for vaginal delivery using the twin-screw hot-melt extrusion method

AU - Mohylyuk, Valentyn

AU - Hutton, Thomas

AU - Dadou, Suha

AU - Tian, Yiwei

AU - Li, Shu

AU - Jones, David

AU - Andrews, Gavin

PY - 2021/5/11

Y1 - 2021/5/11

N2 - The development of sustained-release formulations for vaginal delivery of certain drugs has a big potential toward the increase of the treatment efficiency and patient compliance. One of the possible strategies to formulate sustained release dosage form for vaginal delivery is the incorporation of sustained-release microparticles into the bio-adhesive gel. Objectives of this study were to assess the possibility to formulate matrix system microparticles for vaginal delivery using lipid-based excipient SyncrowaxTM HGLC and optionally Gelucire® 50/13 (G-50/13), Avicel® PH-101 (MCC) or hypromellose type K100M excipients. As model drugs for this purpose were chosen antiretroviral zidovudine (known as azidothymidine; AZT) and antimicrobial metronidazole (MTZ).

AB - The development of sustained-release formulations for vaginal delivery of certain drugs has a big potential toward the increase of the treatment efficiency and patient compliance. One of the possible strategies to formulate sustained release dosage form for vaginal delivery is the incorporation of sustained-release microparticles into the bio-adhesive gel. Objectives of this study were to assess the possibility to formulate matrix system microparticles for vaginal delivery using lipid-based excipient SyncrowaxTM HGLC and optionally Gelucire® 50/13 (G-50/13), Avicel® PH-101 (MCC) or hypromellose type K100M excipients. As model drugs for this purpose were chosen antiretroviral zidovudine (known as azidothymidine; AZT) and antimicrobial metronidazole (MTZ).

M3 - Poster

T2 - 12th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology

Y2 - 11 May 2021 through 14 May 2021

ER -

Formulation of sustained release lipid-based matrix system for vaginal delivery using the twin-screw hot-melt extrusion method

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