Fos imaging reveals that lesions of the anterior thalamic nuclei produce widespread limbic hypoactivity in rats

Trisha Jenkins, R. Dias, E. Amin, M.W. Brown, J.P. Aggleton

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Activity of the immediate early gene c-fos was compared in rats with neurotoxic lesions of the anterior thalamic nuclei and in surgical controls. Fos levels were measured after rats had been placed in a novel room and allowed to run up and down preselected arms of a radial maze. An additional control group showed that in normal rats, this exposure to a novel room leads to a Fos increase in a number of structures, including the anterior thalamic nuclei and hippocampus. In contrast, rats with anterior thalamic lesions were found to have significantly less Fos-positive cells in an array of sites, including the hippocampus (dorsal and ventral), retrosplenial cortex, anterior cingulate cortex, and prelimbic cortex. These results show that anterior thalamic lesions disrupt multiple limbic brain regions, producing hypoactivity in sites associated in rats with spatial memory. Because many of the same sites are implicated in memory processes in humans (e.g., the hippocampus and retrosplenial cortex), this hypoactivity might contribute to diencephalic amnesia.
Original languageEnglish
Pages (from-to)5230-5238
Number of pages9
JournalJournal of Neuroscience
Volume22(12)
Issue number12
Publication statusPublished - 15 Jun 2002

Fingerprint

Anterior Thalamic Nuclei
Hippocampus
Immediate-Early Genes
Amnesia
Gyrus Cinguli
Control Groups
Brain

Cite this

Jenkins, T., Dias, R., Amin, E., Brown, M. W., & Aggleton, J. P. (2002). Fos imaging reveals that lesions of the anterior thalamic nuclei produce widespread limbic hypoactivity in rats. Journal of Neuroscience, 22(12)(12), 5230-5238.
Jenkins, Trisha ; Dias, R. ; Amin, E. ; Brown, M.W. ; Aggleton, J.P. / Fos imaging reveals that lesions of the anterior thalamic nuclei produce widespread limbic hypoactivity in rats. In: Journal of Neuroscience. 2002 ; Vol. 22(12), No. 12. pp. 5230-5238.
@article{447c360117674e46b2a31f6004de360d,
title = "Fos imaging reveals that lesions of the anterior thalamic nuclei produce widespread limbic hypoactivity in rats",
abstract = "Activity of the immediate early gene c-fos was compared in rats with neurotoxic lesions of the anterior thalamic nuclei and in surgical controls. Fos levels were measured after rats had been placed in a novel room and allowed to run up and down preselected arms of a radial maze. An additional control group showed that in normal rats, this exposure to a novel room leads to a Fos increase in a number of structures, including the anterior thalamic nuclei and hippocampus. In contrast, rats with anterior thalamic lesions were found to have significantly less Fos-positive cells in an array of sites, including the hippocampus (dorsal and ventral), retrosplenial cortex, anterior cingulate cortex, and prelimbic cortex. These results show that anterior thalamic lesions disrupt multiple limbic brain regions, producing hypoactivity in sites associated in rats with spatial memory. Because many of the same sites are implicated in memory processes in humans (e.g., the hippocampus and retrosplenial cortex), this hypoactivity might contribute to diencephalic amnesia.",
author = "Trisha Jenkins and R. Dias and E. Amin and M.W. Brown and J.P. Aggleton",
year = "2002",
month = "6",
day = "15",
language = "English",
volume = "22(12)",
pages = "5230--5238",
journal = "Journal of Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "12",

}

Jenkins, T, Dias, R, Amin, E, Brown, MW & Aggleton, JP 2002, 'Fos imaging reveals that lesions of the anterior thalamic nuclei produce widespread limbic hypoactivity in rats', Journal of Neuroscience, vol. 22(12), no. 12, pp. 5230-5238.

Fos imaging reveals that lesions of the anterior thalamic nuclei produce widespread limbic hypoactivity in rats. / Jenkins, Trisha; Dias, R.; Amin, E.; Brown, M.W.; Aggleton, J.P.

In: Journal of Neuroscience, Vol. 22(12), No. 12, 15.06.2002, p. 5230-5238.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Fos imaging reveals that lesions of the anterior thalamic nuclei produce widespread limbic hypoactivity in rats

AU - Jenkins, Trisha

AU - Dias, R.

AU - Amin, E.

AU - Brown, M.W.

AU - Aggleton, J.P.

PY - 2002/6/15

Y1 - 2002/6/15

N2 - Activity of the immediate early gene c-fos was compared in rats with neurotoxic lesions of the anterior thalamic nuclei and in surgical controls. Fos levels were measured after rats had been placed in a novel room and allowed to run up and down preselected arms of a radial maze. An additional control group showed that in normal rats, this exposure to a novel room leads to a Fos increase in a number of structures, including the anterior thalamic nuclei and hippocampus. In contrast, rats with anterior thalamic lesions were found to have significantly less Fos-positive cells in an array of sites, including the hippocampus (dorsal and ventral), retrosplenial cortex, anterior cingulate cortex, and prelimbic cortex. These results show that anterior thalamic lesions disrupt multiple limbic brain regions, producing hypoactivity in sites associated in rats with spatial memory. Because many of the same sites are implicated in memory processes in humans (e.g., the hippocampus and retrosplenial cortex), this hypoactivity might contribute to diencephalic amnesia.

AB - Activity of the immediate early gene c-fos was compared in rats with neurotoxic lesions of the anterior thalamic nuclei and in surgical controls. Fos levels were measured after rats had been placed in a novel room and allowed to run up and down preselected arms of a radial maze. An additional control group showed that in normal rats, this exposure to a novel room leads to a Fos increase in a number of structures, including the anterior thalamic nuclei and hippocampus. In contrast, rats with anterior thalamic lesions were found to have significantly less Fos-positive cells in an array of sites, including the hippocampus (dorsal and ventral), retrosplenial cortex, anterior cingulate cortex, and prelimbic cortex. These results show that anterior thalamic lesions disrupt multiple limbic brain regions, producing hypoactivity in sites associated in rats with spatial memory. Because many of the same sites are implicated in memory processes in humans (e.g., the hippocampus and retrosplenial cortex), this hypoactivity might contribute to diencephalic amnesia.

UR - http://www.scopus.com/inward/record.url?scp=0037096307&partnerID=8YFLogxK

M3 - Article

VL - 22(12)

SP - 5230

EP - 5238

JO - Journal of Neuroscience

JF - Journal of Neuroscience

SN - 0270-6474

IS - 12

ER -