From Plant to Probe: Semi-Synthesis of Labelled Undecaprenol Analogues Allows Rapid Access to Probes for Antibiotic Targets

Rachel Cochrane; Francesca Alexander; Coilin Boland; Susan Fetics; Martin Caffrey; Stephen Cochrane

doi:10.1039/D0CC03388J

From Plant to Probe: Semi-Synthesis of Labelled Undecaprenol Analogues Allows Rapid Access to Probes for Antibiotic Targets

Rachel Cochrane, Francesca Alexander, Coilin Boland, Susan Fetics, Martin Caffrey, Stephen Cochrane^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

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Abstract

Undecaprenol-containing glycolipids (UCGs) are essential precursors of bacterial glycopolymers and glycoproteins. We report a novel semi-synthetic strategy to prepare labelled UCGs directly from undecaprenol. This one-size-fits-all approach offers a concise and efficient method for obtaining labelled-UCGs, which will allow new mechanistic studies and inhibitor screens to be performed on novel antibiotic targets.

Original language	English
Journal	Chemical Communications
Early online date	29 Jun 2020
DOIs	https://doi.org/10.1039/D0CC03388J
Publication status	Early online date - 29 Jun 2020

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10.1039/D0CC03388JLicence: CC BY

From Plant to Probe: Semi-Synthesis of Labelled Undecaprenol Analogues Allows Rapid Access to Probes for Antibiotic Targets
Copyright 2020 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Accepted author manuscript, 954 KBLicence: CC BY

The synthesis and studies of type II porous liquids
Alexander, F. (Author), James, S. (Supervisor) & De Silva, A. (Supervisor), Jul 2022
Student thesis: Doctoral Thesis › Doctor of Philosophy

Stephen Cochrane
- s.cochranequb.acuk
Person: Academic

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title = "From Plant to Probe: Semi-Synthesis of Labelled Undecaprenol Analogues Allows Rapid Access to Probes for Antibiotic Targets",

abstract = "Undecaprenol-containing glycolipids (UCGs) are essential precursors of bacterial glycopolymers and glycoproteins. We report a novel semi-synthetic strategy to prepare labelled UCGs directly from undecaprenol. This one-size-fits-all approach offers a concise and efficient method for obtaining labelled-UCGs, which will allow new mechanistic studies and inhibitor screens to be performed on novel antibiotic targets.",

author = "Rachel Cochrane and Francesca Alexander and Coilin Boland and Susan Fetics and Martin Caffrey and Stephen Cochrane",

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AU - Cochrane, Rachel

AU - Alexander, Francesca

AU - Boland, Coilin

AU - Fetics, Susan

AU - Caffrey, Martin

AU - Cochrane, Stephen

PY - 2020/6/29

Y1 - 2020/6/29

N2 - Undecaprenol-containing glycolipids (UCGs) are essential precursors of bacterial glycopolymers and glycoproteins. We report a novel semi-synthetic strategy to prepare labelled UCGs directly from undecaprenol. This one-size-fits-all approach offers a concise and efficient method for obtaining labelled-UCGs, which will allow new mechanistic studies and inhibitor screens to be performed on novel antibiotic targets.

AB - Undecaprenol-containing glycolipids (UCGs) are essential precursors of bacterial glycopolymers and glycoproteins. We report a novel semi-synthetic strategy to prepare labelled UCGs directly from undecaprenol. This one-size-fits-all approach offers a concise and efficient method for obtaining labelled-UCGs, which will allow new mechanistic studies and inhibitor screens to be performed on novel antibiotic targets.

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M3 - Article

SN - 1359-7345

JO - Chemical Communications

JF - Chemical Communications

ER -

From Plant to Probe: Semi-Synthesis of Labelled Undecaprenol Analogues Allows Rapid Access to Probes for Antibiotic Targets

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The synthesis and studies of type II porous liquids

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Stephen Cochrane

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