From Plant to Probe: Semi-Synthesis of Labelled Undecaprenol Analogues Allows Rapid Access to Probes for Antibiotic Targets

Rachel Cochrane, Francesca Alexander, Coilin Boland, Susan Fetics, Martin Caffrey, Stephen Cochrane*

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Downloads (Pure)

Abstract

Undecaprenol-containing glycolipids (UCGs) are essential precursors of bacterial glycopolymers and glycoproteins. We report a novel semi-synthetic strategy to prepare labelled UCGs directly from undecaprenol. This one-size-fits-all approach offers a concise and efficient method for obtaining labelled-UCGs, which will allow new mechanistic studies and inhibitor screens to be performed on novel antibiotic targets.
Original languageEnglish
JournalChemical Communications
Early online date29 Jun 2020
DOIs
Publication statusEarly online date - 29 Jun 2020

Fingerprint Dive into the research topics of 'From Plant to Probe: Semi-Synthesis of Labelled Undecaprenol Analogues Allows Rapid Access to Probes for Antibiotic Targets'. Together they form a unique fingerprint.

Cite this