Fructose Chemistry

David Timson

Research output: Chapter in Book/Report/Conference proceedingChapter


Fructose is a six-carbon ketose monosaccharide. In aqueous solution and in the crystalline form, the majority of the molecules form ring structures. Of these, the six-membered pyranose form is the most abundant; however, about one-quarter of the molecules are in the five-membered, furanose form. While many of its reactions are similar to those of glucose, the presence of a ketone group in the chain, and the relative ease with which the molecule forms a five-membered furanose ring affects its chemistry and biochemistry. Specific pathways are required to enable organisms to exploit fructose in energy metabolism; these require the enzyme fructokinase and involve the conversion of fructose to glycolytic intermediates. Similarly, specific pathways for the biosynthesis of fructose and fructose-containing polymers, such as inulin, are required. Non-enzymatic glycation (fructation) by fructose has not been as extensively studied as the corresponding reactions with glucose. Nevertheless, especially in diabetic patients and fructose-rich foodstuffs, this reaction is likely to be important.
Original languageEnglish
Title of host publicationDietary Sugars
EditorsV.S. Preedy
PublisherRoyal Society of Chemistry
ISBN (Print)9781849733700
Publication statusPublished - 2012

Publication series

NameFood and Nutritional Components in Focus.

ASJC Scopus subject areas

  • Chemistry(all)


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