Functional interaction of E1AF and Sp1 in glioma invasion.

Hongliang Zong

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)

Abstract

Transcription factor E1AF is widely known to play critical roles in tumor metastasis via directly binding to the promoters of genes involved in tumor migration and invasion. Here, we report for the first time E1AF as a novel binding partner for ubiquitously expressed Sp1 transcription factor. E1AF forms a complex with Sp1, contributes to Sp1 phosphorylation and transcriptional activity, and functions as a mediator between epidermal growth factor and Sp1 phosphorylation and activity. Sp1 functions as a carrier bringing E1AF to the promoter region, thus activating transcription of glioma-related gene for beta1,4-galactosyltransferase V (GalT V; EC 2.4.1.38). Biologically, E1AF functions as a positive invasion regulator in glioma in cooperation with Sp1 partly via up-regulation of GalT V. This report describes a new mechanism of glioma invasion involving a cooperative effort between E1AF and Sp1 transcription factors.
Original languageEnglish
Pages (from-to)8770-8782
Number of pages13
JournalMolecular and Cellular Biology
Volume27(24)
Issue number24
DOIs
Publication statusPublished - Dec 2007

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cell Biology

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