Functionalised Porous Organic Polymers for Bioactive Nitric Oxide Delivery

Sharon Gregg, Rene-Ponce Nze, Bo Xiao

Research output: Contribution to conferenceAbstract

Abstract

Direct delivery of nitric oxide (NO) gas to a wound can promote healing and antimicrobial action, thus having a dual effect to combat the problem of chronic wounds. However delivery of NO gas is problematic due to toxic nature and short half-life, therefore novel NO-donors have been developed as potential topical therapeutic agents for wound care. The effectiveness of therapeutic agents significantly relies on their capability to deliver the desired amount of NO to a target site effectively.
N-nitrosamine and N-diazeniumdiolate moieties are capable of releasing NO in response to external stimuli such as light irradiation and physiological conditions (moisture, pH 7.4, 37 °C), respectively. Secondary amine groups can be converted to N-nitrosamine or N-diazeniumdiolate NO-donor groups to make novel NO-releasing materials. It is hypothesised that porosity can be introduced in the organic framework which will influence the rate of NO release, thus introducing an element of control over release kinetics.
In this work, porous organic polymers with multiple secondary amine sites were synthesised and modified post-synthetically to incorporate N-diazeniumdiolate moieties by reacting with pure NO gas. The subsequent NO release was measured by the Griess method.
Original languageEnglish
Publication statusPublished - 23 Jun 2017
Eventthe 24th Annual SC-CSCST conference-Novel Materials and Surface for Future Engineering - Newcastle, United Kingdom
Duration: 23 Jun 201724 Jun 2017

Conference

Conferencethe 24th Annual SC-CSCST conference-Novel Materials and Surface for Future Engineering
CountryUnited Kingdom
CityNewcastle
Period23/06/201724/06/2017

Fingerprint

Organic polymers
Nitric Oxide
Nitrosamines
Nitric Oxide Donors
Gases
Amines
Poisons
Moisture
Porosity
Irradiation
Kinetics

Keywords

  • bioactive nitric oxide

Cite this

Gregg, S., Nze, R-P., & Xiao, B. (2017). Functionalised Porous Organic Polymers for Bioactive Nitric Oxide Delivery. Abstract from the 24th Annual SC-CSCST conference-Novel Materials and Surface for Future Engineering, Newcastle, United Kingdom.
Gregg, Sharon ; Nze, Rene-Ponce ; Xiao, Bo. / Functionalised Porous Organic Polymers for Bioactive Nitric Oxide Delivery. Abstract from the 24th Annual SC-CSCST conference-Novel Materials and Surface for Future Engineering, Newcastle, United Kingdom.
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abstract = "Direct delivery of nitric oxide (NO) gas to a wound can promote healing and antimicrobial action, thus having a dual effect to combat the problem of chronic wounds. However delivery of NO gas is problematic due to toxic nature and short half-life, therefore novel NO-donors have been developed as potential topical therapeutic agents for wound care. The effectiveness of therapeutic agents significantly relies on their capability to deliver the desired amount of NO to a target site effectively. N-nitrosamine and N-diazeniumdiolate moieties are capable of releasing NO in response to external stimuli such as light irradiation and physiological conditions (moisture, pH 7.4, 37 °C), respectively. Secondary amine groups can be converted to N-nitrosamine or N-diazeniumdiolate NO-donor groups to make novel NO-releasing materials. It is hypothesised that porosity can be introduced in the organic framework which will influence the rate of NO release, thus introducing an element of control over release kinetics. In this work, porous organic polymers with multiple secondary amine sites were synthesised and modified post-synthetically to incorporate N-diazeniumdiolate moieties by reacting with pure NO gas. The subsequent NO release was measured by the Griess method.",
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Gregg, S, Nze, R-P & Xiao, B 2017, 'Functionalised Porous Organic Polymers for Bioactive Nitric Oxide Delivery', the 24th Annual SC-CSCST conference-Novel Materials and Surface for Future Engineering, Newcastle, United Kingdom, 23/06/2017 - 24/06/2017.

Functionalised Porous Organic Polymers for Bioactive Nitric Oxide Delivery. / Gregg, Sharon; Nze, Rene-Ponce; Xiao, Bo.

2017. Abstract from the 24th Annual SC-CSCST conference-Novel Materials and Surface for Future Engineering, Newcastle, United Kingdom.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Functionalised Porous Organic Polymers for Bioactive Nitric Oxide Delivery

AU - Gregg, Sharon

AU - Nze, Rene-Ponce

AU - Xiao, Bo

PY - 2017/6/23

Y1 - 2017/6/23

N2 - Direct delivery of nitric oxide (NO) gas to a wound can promote healing and antimicrobial action, thus having a dual effect to combat the problem of chronic wounds. However delivery of NO gas is problematic due to toxic nature and short half-life, therefore novel NO-donors have been developed as potential topical therapeutic agents for wound care. The effectiveness of therapeutic agents significantly relies on their capability to deliver the desired amount of NO to a target site effectively. N-nitrosamine and N-diazeniumdiolate moieties are capable of releasing NO in response to external stimuli such as light irradiation and physiological conditions (moisture, pH 7.4, 37 °C), respectively. Secondary amine groups can be converted to N-nitrosamine or N-diazeniumdiolate NO-donor groups to make novel NO-releasing materials. It is hypothesised that porosity can be introduced in the organic framework which will influence the rate of NO release, thus introducing an element of control over release kinetics. In this work, porous organic polymers with multiple secondary amine sites were synthesised and modified post-synthetically to incorporate N-diazeniumdiolate moieties by reacting with pure NO gas. The subsequent NO release was measured by the Griess method.

AB - Direct delivery of nitric oxide (NO) gas to a wound can promote healing and antimicrobial action, thus having a dual effect to combat the problem of chronic wounds. However delivery of NO gas is problematic due to toxic nature and short half-life, therefore novel NO-donors have been developed as potential topical therapeutic agents for wound care. The effectiveness of therapeutic agents significantly relies on their capability to deliver the desired amount of NO to a target site effectively. N-nitrosamine and N-diazeniumdiolate moieties are capable of releasing NO in response to external stimuli such as light irradiation and physiological conditions (moisture, pH 7.4, 37 °C), respectively. Secondary amine groups can be converted to N-nitrosamine or N-diazeniumdiolate NO-donor groups to make novel NO-releasing materials. It is hypothesised that porosity can be introduced in the organic framework which will influence the rate of NO release, thus introducing an element of control over release kinetics. In this work, porous organic polymers with multiple secondary amine sites were synthesised and modified post-synthetically to incorporate N-diazeniumdiolate moieties by reacting with pure NO gas. The subsequent NO release was measured by the Griess method.

KW - bioactive nitric oxide

M3 - Abstract

ER -

Gregg S, Nze R-P, Xiao B. Functionalised Porous Organic Polymers for Bioactive Nitric Oxide Delivery. 2017. Abstract from the 24th Annual SC-CSCST conference-Novel Materials and Surface for Future Engineering, Newcastle, United Kingdom.