Fused Deposition Modelling as a Potential Tool for Antimicrobial Dialysis Catheters Manufacturing: New Trends vs. Conventional Approaches

Research output: Contribution to journalReview article

Abstract

The rising rate of individuals with chronic kidney disease (CKD) and ineffective treatment methods for catheter-associated infections in dialysis patients has led to the need for a novel approach to the manufacturing of catheters. The current process requires moulding, which is time consuming, and coated catheters used currently increase the risk of bacterial resistance, toxicity and added expense. 3D printing has gained a lot of attention in recent years and offers the opportunity to rapidly manufacture catheters, that matched to patients through imaging and at a lower cost. Fused Deposition Modelling (FDM) in particular allows thermoplastic polymers to be printed into the desired devices from a model made using computer aided design (CAD). Limitations to FDM include the small range of thermoplastic polymers that are compatible with this form of printing and the high degradation temperature required drugs to be extruded with the polymer. Hot-melt extrusion (HME) allows the potential for antimicrobial drugs to be added to the polymer to create catheters with antimicrobial activity, therefore being able to overcome the issue of increased rates of infection. This review will cover the area of dialysis and catheter related infections, current manufacturing process of catheters and methods to prevent infection, limitations of current processes catheter manufacture, future directions into the manufacture of catheters and how drugs can be incorporated into the polymers to help prevent infection.
Original languageEnglish
Number of pages15
JournalCoatings
Publication statusAccepted - 10 Aug 2019

Fingerprint

dialysis
Dialysis
Catheters
infectious diseases
manufacturing
trends
polymers
drugs
Polymers
printing
kidney diseases
computer aided design
Thermoplastics
Printing
toxicity
Pharmaceutical Preparations
degradation
Molding
Extrusion
Toxicity

Keywords

  • 3D Printing
  • Catheters
  • Coatings
  • Dialysis
  • Infections
  • Manufacturing
  • Polymers
  • Extrusion

Cite this

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title = "Fused Deposition Modelling as a Potential Tool for Antimicrobial Dialysis Catheters Manufacturing: New Trends vs. Conventional Approaches",
abstract = "The rising rate of individuals with chronic kidney disease (CKD) and ineffective treatment methods for catheter-associated infections in dialysis patients has led to the need for a novel approach to the manufacturing of catheters. The current process requires moulding, which is time consuming, and coated catheters used currently increase the risk of bacterial resistance, toxicity and added expense. 3D printing has gained a lot of attention in recent years and offers the opportunity to rapidly manufacture catheters, that matched to patients through imaging and at a lower cost. Fused Deposition Modelling (FDM) in particular allows thermoplastic polymers to be printed into the desired devices from a model made using computer aided design (CAD). Limitations to FDM include the small range of thermoplastic polymers that are compatible with this form of printing and the high degradation temperature required drugs to be extruded with the polymer. Hot-melt extrusion (HME) allows the potential for antimicrobial drugs to be added to the polymer to create catheters with antimicrobial activity, therefore being able to overcome the issue of increased rates of infection. This review will cover the area of dialysis and catheter related infections, current manufacturing process of catheters and methods to prevent infection, limitations of current processes catheter manufacture, future directions into the manufacture of catheters and how drugs can be incorporated into the polymers to help prevent infection.",
keywords = "3D Printing, Catheters, Coatings, Dialysis, Infections, Manufacturing, Polymers, Extrusion",
author = "Essyrose Mathew and {Dominguez Robles}, Juan and {Larraneta Landa}, Eneko and Dimitrios Lamprou",
year = "2019",
month = "8",
day = "10",
language = "English",
journal = "Coatings",
issn = "2079-6412",
publisher = "MDPI AG Basel, Switzerland",

}

TY - JOUR

T1 - Fused Deposition Modelling as a Potential Tool for Antimicrobial Dialysis Catheters Manufacturing: New Trends vs. Conventional Approaches

AU - Mathew, Essyrose

AU - Dominguez Robles, Juan

AU - Larraneta Landa, Eneko

AU - Lamprou, Dimitrios

PY - 2019/8/10

Y1 - 2019/8/10

N2 - The rising rate of individuals with chronic kidney disease (CKD) and ineffective treatment methods for catheter-associated infections in dialysis patients has led to the need for a novel approach to the manufacturing of catheters. The current process requires moulding, which is time consuming, and coated catheters used currently increase the risk of bacterial resistance, toxicity and added expense. 3D printing has gained a lot of attention in recent years and offers the opportunity to rapidly manufacture catheters, that matched to patients through imaging and at a lower cost. Fused Deposition Modelling (FDM) in particular allows thermoplastic polymers to be printed into the desired devices from a model made using computer aided design (CAD). Limitations to FDM include the small range of thermoplastic polymers that are compatible with this form of printing and the high degradation temperature required drugs to be extruded with the polymer. Hot-melt extrusion (HME) allows the potential for antimicrobial drugs to be added to the polymer to create catheters with antimicrobial activity, therefore being able to overcome the issue of increased rates of infection. This review will cover the area of dialysis and catheter related infections, current manufacturing process of catheters and methods to prevent infection, limitations of current processes catheter manufacture, future directions into the manufacture of catheters and how drugs can be incorporated into the polymers to help prevent infection.

AB - The rising rate of individuals with chronic kidney disease (CKD) and ineffective treatment methods for catheter-associated infections in dialysis patients has led to the need for a novel approach to the manufacturing of catheters. The current process requires moulding, which is time consuming, and coated catheters used currently increase the risk of bacterial resistance, toxicity and added expense. 3D printing has gained a lot of attention in recent years and offers the opportunity to rapidly manufacture catheters, that matched to patients through imaging and at a lower cost. Fused Deposition Modelling (FDM) in particular allows thermoplastic polymers to be printed into the desired devices from a model made using computer aided design (CAD). Limitations to FDM include the small range of thermoplastic polymers that are compatible with this form of printing and the high degradation temperature required drugs to be extruded with the polymer. Hot-melt extrusion (HME) allows the potential for antimicrobial drugs to be added to the polymer to create catheters with antimicrobial activity, therefore being able to overcome the issue of increased rates of infection. This review will cover the area of dialysis and catheter related infections, current manufacturing process of catheters and methods to prevent infection, limitations of current processes catheter manufacture, future directions into the manufacture of catheters and how drugs can be incorporated into the polymers to help prevent infection.

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KW - Catheters

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KW - Dialysis

KW - Infections

KW - Manufacturing

KW - Polymers

KW - Extrusion

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JO - Coatings

JF - Coatings

SN - 2079-6412

ER -