Abstract
FcRI activation of mast cells is thought to involve Lyn and Syk kinases proximal to the receptor and the signaling complex organized by the linker for activation of T cells (LAT). We report here that FcRI also uses a Fyn kinase-dependent pathway that does not require Lyn kinase or the adapter LAT for its initiation, but is necessary for mast cell degranulation. Lyn-deficiency enhanced Fyn-dependent signals and degranulation, but inhibited the calcium response. Fyn-deficiency impaired degranulation, whereas Lyn-mediated signaling and calcium was normal. Thus, FcRI-dependent mast cell degranulation involves cross-talk between Fyn and Lyn kinases.
Original language | English |
---|---|
Pages (from-to) | 741-748 |
Number of pages | 8 |
Journal | Nature Immunology |
Volume | 3 (8) |
Issue number | 8 |
DOIs | |
Publication status | Published - Jul 2002 |
ASJC Scopus subject areas
- Immunology