Gaining biological perspectives from schistosome genomes

Geoffrey N Gobert, Hong You, Donald P McManus

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Characterization of the genomic basis underlying schistosome biology is an important strategy for the development of future treatments and interventions. Genomic sequence is now available for the three major clinically relevant schistosome species, Schistosoma mansoni, S. japonicum and S. haematobium, and this information represents an invaluable resource for the future control of human schistosomiasis. The identification of a biologically important, but distinct from the host, schistosome gene product is the ultimate goal for many research groups. While the initial elucidation of the genome of an organism is critical for most biological research, continued improvement or curation of the genome construction should be an ongoing priority. In this review we will discuss prominent recent findings utilizing a systems approach to schistosome biology, as well as the increased use of interference RNA (RNAi). Both of these research strategies are aiming to place parasite genes into a more meaningful biological perspective.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalMolecular and Biochemical Parasitology
Volume196
Issue number1
Early online date27 Jul 2014
DOIs
Publication statusPublished - Aug 2014

Keywords

  • Animals
  • Gene Regulatory Networks
  • Genome, Helminth
  • Schistosoma haematobium
  • Schistosoma japonicum
  • Schistosoma mansoni
  • Systems Biology

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