GDF-15 contributes to proliferation and immune escape of malignant gliomas

Patrick Roth, Markus Junker, Isabel Tritschler, Michel Mittelbronn, Yvonne Dombrowski, Samuel N Breit, Ghazaleh Tabatabai, Wolfgang Wick, Michael Weller, Jörg Wischhusen

Research output: Contribution to journalArticlepeer-review

82 Citations (Scopus)


Growth and differentiation factor (GDF)-15 is a member of the transforming growth factor (TGF)-beta family. GDF-15 is necessary for the maintenance of pregnancy but has also been linked to other physiologic and pathologic conditions.
Original languageEnglish
Pages (from-to)3851-9
Number of pages9
JournalClinical Cancer Research
Issue number15
Publication statusPublished - 01 Aug 2010

Bibliographical note

(c) 2010 AACR.


  • Animals
  • Blotting, Western
  • Brain Neoplasms
  • Cell Line, Tumor
  • Cell Proliferation
  • Cytotoxicity, Immunologic
  • Enzyme-Linked Immunosorbent Assay
  • Glioma
  • Growth Differentiation Factor 15
  • Humans
  • Immunohistochemistry
  • Mice
  • RNA, Small Interfering
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tumor Escape

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