GDF-15 contributes to proliferation and immune escape of malignant gliomas

Patrick Roth; Markus Junker; Isabel Tritschler; Michel Mittelbronn; Yvonne Dombrowski; Samuel N Breit; Ghazaleh Tabatabai; Wolfgang Wick; Michael Weller; Jörg Wischhusen

doi:10.1158/1078-0432.CCR-10-0705

GDF-15 contributes to proliferation and immune escape of malignant gliomas

Patrick Roth
, Markus Junker
, Isabel Tritschler
, Michel Mittelbronn
, Yvonne Dombrowski
, Samuel N Breit
, Ghazaleh Tabatabai
, Wolfgang Wick
, Michael Weller
, Jörg Wischhusen

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

151 Citations (Scopus)

Abstract

Growth and differentiation factor (GDF)-15 is a member of the transforming growth factor (TGF)-beta family. GDF-15 is necessary for the maintenance of pregnancy but has also been linked to other physiologic and pathologic conditions.

Original language	English
Pages (from-to)	3851-9
Number of pages	9
Journal	Clinical Cancer Research
Volume	16
Issue number	15
DOIs	https://doi.org/10.1158/1078-0432.CCR-10-0705
Publication status	Published - 01 Aug 2010

Bibliographical note

Keywords

Animals
Blotting, Western
Brain Neoplasms
Cell Line, Tumor
Cell Proliferation
Cytotoxicity, Immunologic
Enzyme-Linked Immunosorbent Assay
Glioma
Growth Differentiation Factor 15
Humans
Immunohistochemistry
Mice
RNA, Small Interfering
Reverse Transcriptase Polymerase Chain Reaction
Tumor Escape

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10.1158/1078-0432.CCR-10-0705

Cite this

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title = "GDF-15 contributes to proliferation and immune escape of malignant gliomas",

abstract = "Growth and differentiation factor (GDF)-15 is a member of the transforming growth factor (TGF)-beta family. GDF-15 is necessary for the maintenance of pregnancy but has also been linked to other physiologic and pathologic conditions.",

keywords = "Animals, Blotting, Western, Brain Neoplasms, Cell Line, Tumor, Cell Proliferation, Cytotoxicity, Immunologic, Enzyme-Linked Immunosorbent Assay, Glioma, Growth Differentiation Factor 15, Humans, Immunohistochemistry, Mice, RNA, Small Interfering, Reverse Transcriptase Polymerase Chain Reaction, Tumor Escape",

author = "Patrick Roth and Markus Junker and Isabel Tritschler and Michel Mittelbronn and Yvonne Dombrowski and Breit, \{Samuel N\} and Ghazaleh Tabatabai and Wolfgang Wick and Michael Weller and J{\"o}rg Wischhusen",

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doi = "10.1158/1078-0432.CCR-10-0705",

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T1 - GDF-15 contributes to proliferation and immune escape of malignant gliomas

AU - Roth, Patrick

AU - Junker, Markus

AU - Tritschler, Isabel

AU - Mittelbronn, Michel

AU - Dombrowski, Yvonne

AU - Breit, Samuel N

AU - Tabatabai, Ghazaleh

AU - Wick, Wolfgang

AU - Weller, Michael

AU - Wischhusen, Jörg

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Growth and differentiation factor (GDF)-15 is a member of the transforming growth factor (TGF)-beta family. GDF-15 is necessary for the maintenance of pregnancy but has also been linked to other physiologic and pathologic conditions.

AB - Growth and differentiation factor (GDF)-15 is a member of the transforming growth factor (TGF)-beta family. GDF-15 is necessary for the maintenance of pregnancy but has also been linked to other physiologic and pathologic conditions.

KW - Animals

KW - Blotting, Western

KW - Brain Neoplasms

KW - Cell Line, Tumor

KW - Cell Proliferation

KW - Cytotoxicity, Immunologic

KW - Enzyme-Linked Immunosorbent Assay

KW - Glioma

KW - Growth Differentiation Factor 15

KW - Humans

KW - Immunohistochemistry

KW - Mice

KW - RNA, Small Interfering

KW - Reverse Transcriptase Polymerase Chain Reaction

KW - Tumor Escape

U2 - 10.1158/1078-0432.CCR-10-0705

DO - 10.1158/1078-0432.CCR-10-0705

M3 - Article

C2 - 20534737

SN - 1078-0432

VL - 16

SP - 3851

EP - 3859

JO - Clinical Cancer Research

JF - Clinical Cancer Research

IS - 15

ER -

GDF-15 contributes to proliferation and immune escape of malignant gliomas

Abstract

Bibliographical note

Keywords

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