Gender-specific genomic profiling in metastatic colorectal cancer patients treated with 5-fluorouracil and oxaliplatin

Michael A Gordon, Wu Zhang, Dongyun Yang, Syma Iqbal, Anthony El-Khouiery, Fumio Nagashima, Georg Lurje, Melissa Labonte, Peter Wilson, Andy Sherrod, Robert D Ladner, Heinz-Josef Lenz, Melissa LaBonte Wilson

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

AIMS: Survival and response rates in metastatic colorectal cancer remain poor, despite advances in drug development. There is increasing evidence to suggest that gender-specific differences may contribute to poor clinical outcome. We tested the hypothesis that genomic profiling of metastatic colorectal cancer is dependent on gender.

MATERIALS & METHODS: A total of 152 patients with metastatic colorectal cancer who were treated with oxaliplatin and continuous infusion 5-fluorouracil were genotyped for 21 polymorphisms in 13 cancer-related genes by PCR. Classification and regression tree analysis tested for gender-related association of polymorphisms with overall survival, progression-free survival and tumor response.

RESULTS: Classification and regression tree analysis of all polymorphisms, age and race resulted in gender-specific predictors of overall survival, progression-free survival and tumor response. Polymorphisms in the following genes were associated with gender-specific clinical outcome: estrogen receptor β, EGF receptor, xeroderma pigmentosum group D, voltage-gated sodium channel and phospholipase A2.

CONCLUSION: Genetic profiling to predict the clinical outcome of patients with metastatic colorectal cancer may depend on gender.

Original languageEnglish
Pages (from-to)27-39
Number of pages13
JournalPharmacogenomics
Volume12
Issue number1
DOIs
Publication statusPublished - Jan 2011

Keywords

  • Adult
  • Aged
  • Aged, 80 and over
  • Antineoplastic Combined Chemotherapy Protocols
  • Colorectal Neoplasms
  • Disease-Free Survival
  • Female
  • Fluorouracil
  • Gene Expression Profiling
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Organoplatinum Compounds
  • Polymerase Chain Reaction
  • Polymorphism, Genetic
  • Sex Characteristics

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