Gene Expression Meta-Analysis Identifies VDAC1 as a Predictor of Poor Outcome in Early Stage Non-Small Cell Lung Cancer

Claire Grills, Puthen Jithesh, Jaine Blayney, Shu-Dong Zhang, Dean Fennell

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

Background: The bioenergetic status of non-small cell lung cancer correlates with tumour aggressiveness. The voltage dependent anion channel type 1 (VDAC1) is a component of the mitochondrial permeability transition pore, regulates mitochondrial ATP/ADP exchange suggesting that its over-expression could be associated with energy dependent processes including increased proliferation and invasiveness. To test this hypothesis, we conducted an in vivo gene-expression meta-analysis of surgically resected non-small cell lung cancer (NSCLC) using 602 individual expression profiles, to examine the impact of VDAC1 on survival.
Original languageEnglish
Article numbere14635
Pages (from-to)e14635
Number of pages1
JournalPLoS ONE
Volume6
Issue number1
DOIs
Publication statusPublished - Jan 2011

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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