TY - JOUR
T1 - General and abdominal adiposity and the risk of Parkinson's disease: A prospective cohort study
AU - Riso, Lukas
AU - Kaaks, Rudolf
AU - Kühn, Tilman
AU - Sookthai, Disorn
AU - Forsgren, Lars
AU - Trupp, Miles
AU - Trichopoulou, Antonia
AU - La Vecchia, Carlo
AU - Karakatsani, Anna
AU - Gavrila, Diana
AU - Ferrari, Pietro
AU - Freisling, Heinz
AU - Petersson, Jesper
AU - Lewan, Susanne
AU - Vermeulen, Roel Ch
AU - Panico, Salvatore
AU - Masala, Giovanna
AU - Ardanaz, Eva
AU - Krogh, Vittorio
AU - Perneczky, Robert
AU - Middleton, Lefkos T
AU - Mokoroa, Olatz
AU - Sacerdote, Carlotta
AU - Sieri, Sabrina
AU - Hayat, Shabina A
AU - Brayne, Carol
AU - Riboli, Elio
AU - Vineis, Paolo
AU - Gallo, Valentina
AU - Katzke, Verena A
N1 - Copyright © 2019 Elsevier Ltd. All rights reserved.
PY - 2019/5/1
Y1 - 2019/5/1
N2 - INTRODUCTION: Due to demographic change, an increase in the frequency of Parkinson's disease (PD) patients is expected in the future and, thus, the identification of modifiable risk factors is urgently needed. We aimed to examine the associations of body mass index (BMI) and waist circumference (WC) with incident PD.METHODS: In 13 of the 23 centers of the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a total of 734 incident cases of PD were identified between 1992 and 2012 with a mean follow-up of 12 years. Cox proportional hazards regression was used to calculate hazard ratios (HR) with 95% confidence intervals (CI). We modelled anthropometric variables as continuous and categorical exposures and performed subgroup analyses by potential effect modifiers including sex and smoking.RESULTS: We found no association between BMI, WC and incident PD, neither among men nor among women. Among never and former smokers, BMI and waist circumference were also not associated with PD risk. For male smokers, however, we observed a statistically significant inverse association between BMI and PD risk (HR 0.51, 95%CI: 0.30, 0.84) and the opposite for women, i.e. a significant direct association of BMI (HR 1.79, 95%CI: 1.04, 3.08) and waist circumference (HR 1.64, 95%CI: 1.03, 2.61) with risk of PD.CONCLUSION: Our data revealed no association between excess weight and PD risk but a possible interaction between anthropometry, sex and smoking.
AB - INTRODUCTION: Due to demographic change, an increase in the frequency of Parkinson's disease (PD) patients is expected in the future and, thus, the identification of modifiable risk factors is urgently needed. We aimed to examine the associations of body mass index (BMI) and waist circumference (WC) with incident PD.METHODS: In 13 of the 23 centers of the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a total of 734 incident cases of PD were identified between 1992 and 2012 with a mean follow-up of 12 years. Cox proportional hazards regression was used to calculate hazard ratios (HR) with 95% confidence intervals (CI). We modelled anthropometric variables as continuous and categorical exposures and performed subgroup analyses by potential effect modifiers including sex and smoking.RESULTS: We found no association between BMI, WC and incident PD, neither among men nor among women. Among never and former smokers, BMI and waist circumference were also not associated with PD risk. For male smokers, however, we observed a statistically significant inverse association between BMI and PD risk (HR 0.51, 95%CI: 0.30, 0.84) and the opposite for women, i.e. a significant direct association of BMI (HR 1.79, 95%CI: 1.04, 3.08) and waist circumference (HR 1.64, 95%CI: 1.03, 2.61) with risk of PD.CONCLUSION: Our data revealed no association between excess weight and PD risk but a possible interaction between anthropometry, sex and smoking.
U2 - 10.1016/j.parkreldis.2019.01.019
DO - 10.1016/j.parkreldis.2019.01.019
M3 - Article
C2 - 30772279
SN - 1353-8020
VL - 62
SP - 98
EP - 104
JO - Parkinsonism & Related Disorders
JF - Parkinsonism & Related Disorders
ER -
