Genetic association suggests that SMOC1 mediates between prenatal sex hormones and digit ratio

Adam J Lawrance-Owen, Gary Bargary, Jenny M Bosten, Patrick T Goodbourn, Ruth E Hogg, J D Mollon

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)

Abstract

Men and women differ statistically in the relative lengths of their index and ring fingers; and the ratio of these lengths has been used as a biomarker for prenatal testosterone. The ratio has been correlated with a wide range of traits and conditions including prostate cancer, obesity, autism, ADHD, and sexual orientation. In a genome-wide association study of 979 healthy adults, we find that digit ratio is strongly associated with variation upstream of SMOC1 (rs4902759: P = 1.41 × 10(-8)) and a meta-analysis of this and an independent study shows a probability of P = 1.5 × 10(-11). The protein encoded by SMOC1 has recently been shown to play a critical role in limb development; its expression in prostate tissue is dependent on sex hormones, and it has been implicated in the sexually dimorphic development of the gonads. We put forward the hypothesis that SMOC1 provides a link between prenatal hormone exposure and digit ratio.
Original languageEnglish
Pages (from-to)415-421
JournalHuman genetics
Volume132
Issue number4
Early online date22 Dec 2012
DOIs
Publication statusPublished - Apr 2013

ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Fingerprint Dive into the research topics of 'Genetic association suggests that SMOC1 mediates between prenatal sex hormones and digit ratio'. Together they form a unique fingerprint.

Cite this