Genetic examination of SETD7 and SUV39H1/H2 methyltransferases and the risk of diabetes complications in patients with type 1 diabetes

Anna Syreeni, Assam El-Osta, Carol Forsblom, Niina Sandholm, Maikki Parkkonen, Lise Tarnow, Hans-Henrik Parving, Amy J McKnight, Alexander P Maxwell, Mark E Cooper, Per-Henrik Groop, FinnDiane Study Group

Research output: Contribution to journalArticlepeer-review

44 Citations (Scopus)

Abstract

Hyperglycemia plays a pivotal role in the development and progression of vascular complications, which are the major sources of morbidity and mortality in diabetes. Furthermore, these vascular complications often persist and progress despite improved glucose control, possibly as a result of prior episodes of hyperglycemia. Epigenetic modifications mediated by histone methyltransferases are associated with gene-activating events that promote enhanced expression of key proinflammatory molecules implicated in vascular injury. In this study, we investigated genetic polymorphisms of the SETD7, SUV39H1, and SUV39H2 methyltransferases as predictors of risk for micro- and macrovascular complications in type 1 diabetes.
Original languageEnglish
Pages (from-to)3073-80
Number of pages8
JournalDiabetes
Volume60
Issue number11
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Adult
  • Cardiovascular Diseases
  • Cohort Studies
  • Diabetes Mellitus, Type 1
  • Diabetic Angiopathies
  • Diabetic Nephropathies
  • Diabetic Retinopathy
  • Exons
  • Female
  • Finland
  • Gene Frequency
  • Genetic Association Studies
  • Histone-Lysine N-Methyltransferase
  • Humans
  • Male
  • Methyltransferases
  • Microvessels
  • Middle Aged
  • Polymorphism, Single Nucleotide
  • Repressor Proteins

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