Genetic polymorphisms and kidney transplant outcomes

Sourabh Chand, Amy Jayne McKnight, Richard Borrows

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)

Abstract

Purpose of review: Gene polymorphism studies are growing at a quasiexponential rate and aim to improve immediate and long-term outcomes in renal transplantation. This review highlights recent evidence and potential future directions for genetic research studies.

Recent findings: Studies are largely based on immunity, inflammation and pharmacogenetics, investigating mostly 'surrogate' outcomes with sometimes conflicting results. However, the last 12 months has also heralded the emergence of important genome-wide association studies on transplantation, more robust replicated multicentre analyses of candidate gene variants, meta-analyses, and an increasing interest in copy number variation and donor genetics.

Summary: These studies set the scene for further investigation, aiming to understand pathways of disease and biomarkers of risk, and are leading to a greater understanding of the biology of transplantation. Future studies will require focus on donor : recipient and gene : environment interactions, and an integrated approach of 'transplantomics' to evaluate long-term outcomes in multinational collaborations.
Original languageEnglish
Pages (from-to)605-610
JournalCurrent Opinion in Nephrology and Hypertension
Volume23
Issue number6
Early online date04 Sep 2014
DOIs
Publication statusPublished - Nov 2014

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