Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia

Richard E Straub; Yuxin Jiang; Charles J MacLean; Yunlong Ma; Bradley T Webb; Maxim V Myakishev; Carole Harris-Kerr; Brandon Wormley; Hannah Sadek; Bharat Kadambi; Anthony J Cesare; Avi Gibberman; Xu Wang; F Anthony O'Neill; Dermot Walsh; Kenneth S Kendler

doi:10.1086/341750

Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia

Richard E Straub
, Yuxin Jiang
, Charles J MacLean
, Yunlong Ma
, Bradley T Webb
, Maxim V Myakishev
, Carole Harris-Kerr
, Brandon Wormley
, Hannah Sadek
, Bharat Kadambi
, Anthony J Cesare
, Avi Gibberman
, Xu Wang
, F Anthony O'Neill
, Dermot Walsh
, Kenneth S Kendler

Research output: Contribution to journal › Article › peer-review

743 Citations (Scopus)

Abstract

Prior evidence has supported the existence of multiple susceptibility genes for schizophrenia. Multipoint linkage analysis of the 270 Irish high-density pedigrees that we have studied, as well as results from several other samples, suggest that at least one such gene is located in region 6p24-21. In the present study, family-based association analysis of 36 simple sequence-length-polymorphism markers and of 17 SNP markers implicated two regions, separated by approximately 7 Mb. The first region, and the focus of this report, is 6p22.3. In this region, single-nucleotide polymorphisms within the 140-kb gene DTNBP1 (dystrobrevin-binding protein 1, or dysbindin) are strongly associated with schizophrenia. Uncorrected, empirical P values produced by the program TRANSMIT were significant (P

Original language	English
Pages (from-to)	337-48
Number of pages	12
Journal	The American Journal of Human Genetics
Volume	71
Issue number	2
DOIs	https://doi.org/10.1086/341750
Publication status	Published - Aug 2002

Keywords

Animals
Carrier Proteins
Chromosome Mapping
Chromosomes, Human, Pair 6
Female
Genetic Markers
Haplotypes
Humans
Male
Mice
Pedigree
Polymorphism, Single Nucleotide
Schizophrenia

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10.1086/341750

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Straub, R. E., Jiang, Y., MacLean, C. J., Ma, Y., Webb, B. T., Myakishev, M. V., Harris-Kerr, C., Wormley, B., Sadek, H., Kadambi, B., Cesare, A. J., Gibberman, A., Wang, X., O'Neill, F. A., Walsh, D., & Kendler, K. S. (2002). Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia. The American Journal of Human Genetics, 71(2), 337-48. https://doi.org/10.1086/341750

@article{7b5f25adf51a44fab7a7a1de37f8efb0,

title = "Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia",

abstract = "Prior evidence has supported the existence of multiple susceptibility genes for schizophrenia. Multipoint linkage analysis of the 270 Irish high-density pedigrees that we have studied, as well as results from several other samples, suggest that at least one such gene is located in region 6p24-21. In the present study, family-based association analysis of 36 simple sequence-length-polymorphism markers and of 17 SNP markers implicated two regions, separated by approximately 7 Mb. The first region, and the focus of this report, is 6p22.3. In this region, single-nucleotide polymorphisms within the 140-kb gene DTNBP1 (dystrobrevin-binding protein 1, or dysbindin) are strongly associated with schizophrenia. Uncorrected, empirical P values produced by the program TRANSMIT were significant (P",

keywords = "Animals, Carrier Proteins, Chromosome Mapping, Chromosomes, Human, Pair 6, Female, Genetic Markers, Haplotypes, Humans, Male, Mice, Pedigree, Polymorphism, Single Nucleotide, Schizophrenia",

author = "Straub, \{Richard E\} and Yuxin Jiang and MacLean, \{Charles J\} and Yunlong Ma and Webb, \{Bradley T\} and Myakishev, \{Maxim V\} and Carole Harris-Kerr and Brandon Wormley and Hannah Sadek and Bharat Kadambi and Cesare, \{Anthony J\} and Avi Gibberman and Xu Wang and O'Neill, \{F Anthony\} and Dermot Walsh and Kendler, \{Kenneth S\}",

year = "2002",

month = aug,

doi = "10.1086/341750",

language = "English",

volume = "71",

pages = "337--48",

journal = "The American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Cell Press",

number = "2",

}

Straub, RE, Jiang, Y, MacLean, CJ, Ma, Y, Webb, BT, Myakishev, MV, Harris-Kerr, C, Wormley, B, Sadek, H, Kadambi, B, Cesare, AJ, Gibberman, A, Wang, X, O'Neill, FA, Walsh, D & Kendler, KS 2002, 'Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia', The American Journal of Human Genetics, vol. 71, no. 2, pp. 337-48. https://doi.org/10.1086/341750

TY - JOUR

T1 - Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia

AU - Straub, Richard E

AU - Jiang, Yuxin

AU - MacLean, Charles J

AU - Ma, Yunlong

AU - Webb, Bradley T

AU - Myakishev, Maxim V

AU - Harris-Kerr, Carole

AU - Wormley, Brandon

AU - Sadek, Hannah

AU - Kadambi, Bharat

AU - Cesare, Anthony J

AU - Gibberman, Avi

AU - Wang, Xu

AU - O'Neill, F Anthony

AU - Walsh, Dermot

AU - Kendler, Kenneth S

PY - 2002/8

Y1 - 2002/8

N2 - Prior evidence has supported the existence of multiple susceptibility genes for schizophrenia. Multipoint linkage analysis of the 270 Irish high-density pedigrees that we have studied, as well as results from several other samples, suggest that at least one such gene is located in region 6p24-21. In the present study, family-based association analysis of 36 simple sequence-length-polymorphism markers and of 17 SNP markers implicated two regions, separated by approximately 7 Mb. The first region, and the focus of this report, is 6p22.3. In this region, single-nucleotide polymorphisms within the 140-kb gene DTNBP1 (dystrobrevin-binding protein 1, or dysbindin) are strongly associated with schizophrenia. Uncorrected, empirical P values produced by the program TRANSMIT were significant (P

AB - Prior evidence has supported the existence of multiple susceptibility genes for schizophrenia. Multipoint linkage analysis of the 270 Irish high-density pedigrees that we have studied, as well as results from several other samples, suggest that at least one such gene is located in region 6p24-21. In the present study, family-based association analysis of 36 simple sequence-length-polymorphism markers and of 17 SNP markers implicated two regions, separated by approximately 7 Mb. The first region, and the focus of this report, is 6p22.3. In this region, single-nucleotide polymorphisms within the 140-kb gene DTNBP1 (dystrobrevin-binding protein 1, or dysbindin) are strongly associated with schizophrenia. Uncorrected, empirical P values produced by the program TRANSMIT were significant (P

KW - Animals

KW - Carrier Proteins

KW - Chromosome Mapping

KW - Chromosomes, Human, Pair 6

KW - Female

KW - Genetic Markers

KW - Haplotypes

KW - Humans

KW - Male

KW - Mice

KW - Pedigree

KW - Polymorphism, Single Nucleotide

KW - Schizophrenia

U2 - 10.1086/341750

DO - 10.1086/341750

M3 - Article

C2 - 12098102

SN - 0002-9297

VL - 71

SP - 337

EP - 348

JO - The American Journal of Human Genetics

JF - The American Journal of Human Genetics

IS - 2

ER -

Genetic variation in the 6p22.3 gene DTNBP1, the human ortholog of the mouse dysbindin gene, is associated with schizophrenia

Abstract

Keywords

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