Genetics of Pituitary Tumours

Paul Benjamin Loughrey, Márta Korbonits

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)


Pituitary tumours are relatively common in the general population. Most often they occur sporadically, with somatic mutations accounting for a significant minority of somatotroph and corticotroph adenomas. Pituitary tumours can also develop secondary to germline mutations as part of a complex syndrome or as familial isolated pituitary adenomas. Tumours occurring in a familial setting may present at a younger age and can behave more aggressively with resistance to treatment. This chapter will focus on the genetics and molecular pathogenesis of pituitary tumours.

Original languageEnglish
Title of host publicationGenetics of Endocrine Diseases and Syndromes
EditorsPeter Igaz, Attila Patocs
Number of pages41
ISBN (Electronic)978-3-030-25905-1
Publication statusPublished - 07 Oct 2019
Externally publishedYes

Publication series

NameExperientia Supplementum
PublisherSpringer International Publishing AG
ISSN (Print)1664-431X


  • ACTH-Secreting Pituitary Adenoma/genetics
  • Germ-Line Mutation
  • Growth Hormone-Secreting Pituitary Adenoma/genetics
  • Humans
  • Pituitary Neoplasms/genetics


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