Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia

Cathryn M Lewis; Douglas F Levinson; Lesley H Wise; Lynn E DeLisi; Richard E Straub; Iiris Hovatta; Nigel M Williams; Sibylle G Schwab; Ann E Pulver; Stephen V Faraone; Linda M Brzustowicz; Charles A Kaufmann; David L Garver; Hugh M D Gurling; Eva Lindholm; Hilary Coon; Hans W Moises; William Byerley; Sarah H Shaw; Andrea Mesen; Robin Sherrington; F Anthony O'Neill; Dermot Walsh; Kenneth S Kendler; Jesper Ekelund; Tiina Paunio; Jouko Lönnqvist; Leena Peltonen; Michael C O'Donovan; Michael J Owen; Dieter B Wildenauer; Wolfgang Maier; Gerald Nestadt; Jean-Louis Blouin; Stylianos E Antonarakis; Bryan J Mowry; Jeremy M Silverman; Raymond R Crowe; C Robert Cloninger; Ming T Tsuang; Dolores Malaspina; Jill M Harkavy-Friedman; Dragan M Svrakic; Anne S Bassett; Jennifer Holcomb; Gursharan Kalsi; Andrew McQuillin; Jon Brynjolfson; Thordur Sigmundsson; Hannes Petursson; Elena Jazin; Tomas Zoëga; Tomas Helgason

doi:10.1086/376549

Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia

Cathryn M Lewis, Douglas F Levinson, Lesley H Wise, Lynn E DeLisi, Richard E Straub, Iiris Hovatta, Nigel M Williams, Sibylle G Schwab, Ann E Pulver, Stephen V Faraone, Linda M Brzustowicz, Charles A Kaufmann, David L Garver, Hugh M D Gurling, Eva Lindholm, Hilary Coon, Hans W Moises, William Byerley, Sarah H Shaw, Andrea MesenRobin Sherrington, F Anthony O'Neill, Dermot Walsh, Kenneth S Kendler, Jesper Ekelund, Tiina Paunio, Jouko Lönnqvist, Leena Peltonen, Michael C O'Donovan, Michael J Owen, Dieter B Wildenauer, Wolfgang Maier, Gerald Nestadt, Jean-Louis Blouin, Stylianos E Antonarakis, Bryan J Mowry, Jeremy M Silverman, Raymond R Crowe, C Robert Cloninger, Ming T Tsuang, Dolores Malaspina, Jill M Harkavy-Friedman, Dragan M Svrakic, Anne S Bassett, Jennifer Holcomb, Gursharan Kalsi, Andrew McQuillin, Jon Brynjolfson, Thordur Sigmundsson, Hannes Petursson, Elena Jazin, Tomas Zoëga, Tomas Helgason

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Abstract

Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To assess evidence for linkage across studies, rank-based genome scan meta-analysis (GSMA) was applied to data from 20 schizophrenia genome scans. Each marker for each scan was assigned to 1 of 120 30-cM bins, with the bins ranked by linkage scores (1 = most significant) and the ranks averaged across studies (R(avg)) and then weighted for sample size (N(sqrt)[affected casess]). A permutation test was used to compute the probability of observing, by chance, each bin's average rank (P(AvgRnk)) or of observing it for a bin with the same place (first, second, etc.) in the order of average ranks in each permutation (P(ord)). The GSMA produced significant genomewide evidence for linkage on chromosome 2q (PAvgRnk

Original language	English
Pages (from-to)	34-48
Number of pages	15
Journal	The American Journal of Human Genetics
Volume	73
Issue number	1
DOIs	https://doi.org/10.1086/376549
Publication status	Published - Jul 2003

Keywords

Bipolar Disorder
Genome, Human
Genotype
Humans
Schizophrenia

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Lewis, C. M., Levinson, D. F., Wise, L. H., DeLisi, L. E., Straub, R. E., Hovatta, I., Williams, N. M., Schwab, S. G., Pulver, A. E., Faraone, S. V., Brzustowicz, L. M., Kaufmann, C. A., Garver, D. L., Gurling, H. M. D., Lindholm, E., Coon, H., Moises, H. W., Byerley, W., Shaw, S. H., ... Helgason, T. (2003). Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. The American Journal of Human Genetics, 73(1), 34-48. https://doi.org/10.1086/376549

@article{753fb7d1f61442378dd935997dca54db,

title = "Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia",

abstract = "Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To assess evidence for linkage across studies, rank-based genome scan meta-analysis (GSMA) was applied to data from 20 schizophrenia genome scans. Each marker for each scan was assigned to 1 of 120 30-cM bins, with the bins ranked by linkage scores (1 = most significant) and the ranks averaged across studies (R(avg)) and then weighted for sample size (N(sqrt)[affected casess]). A permutation test was used to compute the probability of observing, by chance, each bin's average rank (P(AvgRnk)) or of observing it for a bin with the same place (first, second, etc.) in the order of average ranks in each permutation (P(ord)). The GSMA produced significant genomewide evidence for linkage on chromosome 2q (PAvgRnk",

keywords = "Bipolar Disorder, Genome, Human, Genotype, Humans, Schizophrenia",

author = "Lewis, {Cathryn M} and Levinson, {Douglas F} and Wise, {Lesley H} and DeLisi, {Lynn E} and Straub, {Richard E} and Iiris Hovatta and Williams, {Nigel M} and Schwab, {Sibylle G} and Pulver, {Ann E} and Faraone, {Stephen V} and Brzustowicz, {Linda M} and Kaufmann, {Charles A} and Garver, {David L} and Gurling, {Hugh M D} and Eva Lindholm and Hilary Coon and Moises, {Hans W} and William Byerley and Shaw, {Sarah H} and Andrea Mesen and Robin Sherrington and O'Neill, {F Anthony} and Dermot Walsh and Kendler, {Kenneth S} and Jesper Ekelund and Tiina Paunio and Jouko L{\"o}nnqvist and Leena Peltonen and O'Donovan, {Michael C} and Owen, {Michael J} and Wildenauer, {Dieter B} and Wolfgang Maier and Gerald Nestadt and Jean-Louis Blouin and Antonarakis, {Stylianos E} and Mowry, {Bryan J} and Silverman, {Jeremy M} and Crowe, {Raymond R} and Cloninger, {C Robert} and Tsuang, {Ming T} and Dolores Malaspina and Harkavy-Friedman, {Jill M} and Svrakic, {Dragan M} and Bassett, {Anne S} and Jennifer Holcomb and Gursharan Kalsi and Andrew McQuillin and Jon Brynjolfson and Thordur Sigmundsson and Hannes Petursson and Elena Jazin and Tomas Zo{\"e}ga and Tomas Helgason",

year = "2003",

month = jul,

doi = "10.1086/376549",

language = "English",

volume = "73",

pages = "34--48",

journal = "The American Journal of Human Genetics",

issn = "0002-9297",

publisher = "Cell Press",

number = "1",

}

Lewis, CM, Levinson, DF, Wise, LH, DeLisi, LE, Straub, RE, Hovatta, I, Williams, NM, Schwab, SG, Pulver, AE, Faraone, SV, Brzustowicz, LM, Kaufmann, CA, Garver, DL, Gurling, HMD, Lindholm, E, Coon, H, Moises, HW, Byerley, W, Shaw, SH, Mesen, A, Sherrington, R, O'Neill, FA, Walsh, D, Kendler, KS, Ekelund, J, Paunio, T, Lönnqvist, J, Peltonen, L, O'Donovan, MC, Owen, MJ, Wildenauer, DB, Maier, W, Nestadt, G, Blouin, J-L, Antonarakis, SE, Mowry, BJ, Silverman, JM, Crowe, RR, Cloninger, CR, Tsuang, MT, Malaspina, D, Harkavy-Friedman, JM, Svrakic, DM, Bassett, AS, Holcomb, J, Kalsi, G, McQuillin, A, Brynjolfson, J, Sigmundsson, T, Petursson, H, Jazin, E, Zoëga, T & Helgason, T 2003, 'Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia', The American Journal of Human Genetics, vol. 73, no. 1, pp. 34-48. https://doi.org/10.1086/376549

TY - JOUR

T1 - Genome scan meta-analysis of schizophrenia and bipolar disorder, part II

T2 - Schizophrenia

AU - Lewis, Cathryn M

AU - Levinson, Douglas F

AU - Wise, Lesley H

AU - DeLisi, Lynn E

AU - Straub, Richard E

AU - Hovatta, Iiris

AU - Williams, Nigel M

AU - Schwab, Sibylle G

AU - Pulver, Ann E

AU - Faraone, Stephen V

AU - Brzustowicz, Linda M

AU - Kaufmann, Charles A

AU - Garver, David L

AU - Gurling, Hugh M D

AU - Lindholm, Eva

AU - Coon, Hilary

AU - Moises, Hans W

AU - Byerley, William

AU - Shaw, Sarah H

AU - Mesen, Andrea

AU - Sherrington, Robin

AU - O'Neill, F Anthony

AU - Walsh, Dermot

AU - Kendler, Kenneth S

AU - Ekelund, Jesper

AU - Paunio, Tiina

AU - Lönnqvist, Jouko

AU - Peltonen, Leena

AU - O'Donovan, Michael C

AU - Owen, Michael J

AU - Wildenauer, Dieter B

AU - Maier, Wolfgang

AU - Nestadt, Gerald

AU - Blouin, Jean-Louis

AU - Antonarakis, Stylianos E

AU - Mowry, Bryan J

AU - Silverman, Jeremy M

AU - Crowe, Raymond R

AU - Cloninger, C Robert

AU - Tsuang, Ming T

AU - Malaspina, Dolores

AU - Harkavy-Friedman, Jill M

AU - Svrakic, Dragan M

AU - Bassett, Anne S

AU - Holcomb, Jennifer

AU - Kalsi, Gursharan

AU - McQuillin, Andrew

AU - Brynjolfson, Jon

AU - Sigmundsson, Thordur

AU - Petursson, Hannes

AU - Jazin, Elena

AU - Zoëga, Tomas

AU - Helgason, Tomas

PY - 2003/7

Y1 - 2003/7

N2 - Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To assess evidence for linkage across studies, rank-based genome scan meta-analysis (GSMA) was applied to data from 20 schizophrenia genome scans. Each marker for each scan was assigned to 1 of 120 30-cM bins, with the bins ranked by linkage scores (1 = most significant) and the ranks averaged across studies (R(avg)) and then weighted for sample size (N(sqrt)[affected casess]). A permutation test was used to compute the probability of observing, by chance, each bin's average rank (P(AvgRnk)) or of observing it for a bin with the same place (first, second, etc.) in the order of average ranks in each permutation (P(ord)). The GSMA produced significant genomewide evidence for linkage on chromosome 2q (PAvgRnk

AB - Schizophrenia is a common disorder with high heritability and a 10-fold increase in risk to siblings of probands. Replication has been inconsistent for reports of significant genetic linkage. To assess evidence for linkage across studies, rank-based genome scan meta-analysis (GSMA) was applied to data from 20 schizophrenia genome scans. Each marker for each scan was assigned to 1 of 120 30-cM bins, with the bins ranked by linkage scores (1 = most significant) and the ranks averaged across studies (R(avg)) and then weighted for sample size (N(sqrt)[affected casess]). A permutation test was used to compute the probability of observing, by chance, each bin's average rank (P(AvgRnk)) or of observing it for a bin with the same place (first, second, etc.) in the order of average ranks in each permutation (P(ord)). The GSMA produced significant genomewide evidence for linkage on chromosome 2q (PAvgRnk

KW - Bipolar Disorder

KW - Genome, Human

KW - Genotype

KW - Humans

KW - Schizophrenia

U2 - 10.1086/376549

DO - 10.1086/376549

M3 - Article

C2 - 12802786

SN - 0002-9297

VL - 73

SP - 34

EP - 48

JO - The American Journal of Human Genetics

JF - The American Journal of Human Genetics

IS - 1

ER -

Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia

Abstract

Keywords

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