Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10

N Orr, E W Hill, J Gu, P Govindarajan, J Conroy, E M van Grevenhof, B J Ducro, J A M van Arendonk, J H Knaap, P R van Weeren, D E Machugh, S Ennis, P A J Brama

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10 Citations (Scopus)

Abstract

Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10(-7) ) and chromosome 10 (BIEC2-121323; P = 2.62 × 10(-7) ).

Original languageEnglish
Pages (from-to)408-12
Number of pages5
JournalAnimal Genetics
Volume44
Issue number4
DOIs
Publication statusPublished - Aug 2013
Externally publishedYes

Keywords

  • Animals
  • Breeding
  • Chromosome Mapping
  • Chromosomes, Mammalian
  • Female
  • Genetic Loci
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Genotype
  • Haplotypes
  • Horse Diseases
  • Horses
  • Joint Diseases
  • Male
  • Osteochondrosis
  • Phenotype
  • Polymorphism, Single Nucleotide
  • Radiography
  • Journal Article

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  • Cite this

    Orr, N., Hill, E. W., Gu, J., Govindarajan, P., Conroy, J., van Grevenhof, E. M., Ducro, B. J., van Arendonk, J. A. M., Knaap, J. H., van Weeren, P. R., Machugh, D. E., Ennis, S., & Brama, P. A. J. (2013). Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10. Animal Genetics, 44(4), 408-12. https://doi.org/10.1111/age.12016