Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10

N Orr; E W Hill; J Gu; P Govindarajan; J Conroy; E M van Grevenhof; B J Ducro; J A M van Arendonk; J H Knaap; P R van Weeren; D E Machugh; S Ennis; P A J Brama

doi:10.1111/age.12016

Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10

N Orr
, E W Hill
, J Gu
, P Govindarajan
, J Conroy
, E M van Grevenhof
, B J Ducro
, J A M van Arendonk
, J H Knaap
, P R van Weeren
, D E Machugh
, S Ennis
, P A J Brama

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10(-7) ) and chromosome 10 (BIEC2-121323; P = 2.62 × 10(-7) ).

Original language	English
Pages (from-to)	408-12
Number of pages	5
Journal	Animal Genetics
Volume	44
Issue number	4
DOIs	https://doi.org/10.1111/age.12016
Publication status	Published - Aug 2013
Externally published	Yes

Keywords

Animals
Breeding
Chromosome Mapping
Chromosomes, Mammalian
Female
Genetic Loci
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Haplotypes
Horse Diseases
Horses
Joint Diseases
Male
Osteochondrosis
Phenotype
Polymorphism, Single Nucleotide
Radiography
Journal Article

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10.1111/age.12016

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Orr, N., Hill, E. W., Gu, J., Govindarajan, P., Conroy, J., van Grevenhof, E. M., Ducro, B. J., van Arendonk, J. A. M., Knaap, J. H., van Weeren, P. R., Machugh, D. E., Ennis, S., & Brama, P. A. J. (2013). Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10. Animal Genetics, 44(4), 408-12. https://doi.org/10.1111/age.12016

@article{32f8caa437f64d79bc0c9ae6e34a87ac,

title = "Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10",

abstract = "Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10(-7) ) and chromosome 10 (BIEC2-121323; P = 2.62 × 10(-7) ).",

keywords = "Animals, Breeding, Chromosome Mapping, Chromosomes, Mammalian, Female, Genetic Loci, Genetic Predisposition to Disease, Genome-Wide Association Study, Genotype, Haplotypes, Horse Diseases, Horses, Joint Diseases, Male, Osteochondrosis, Phenotype, Polymorphism, Single Nucleotide, Radiography, Journal Article",

author = "N Orr and Hill, \{E W\} and J Gu and P Govindarajan and J Conroy and \{van Grevenhof\}, \{E M\} and Ducro, \{B J\} and \{van Arendonk\}, \{J A M\} and Knaap, \{J H\} and \{van Weeren\}, \{P R\} and Machugh, \{D E\} and S Ennis and Brama, \{P A J\}",

note = "{\textcopyright} 2012 The Authors, Animal Genetics {\textcopyright} 2012 Stichting International Foundation for Animal Genetics.",

year = "2013",

month = aug,

doi = "10.1111/age.12016",

language = "English",

volume = "44",

pages = "408--12",

journal = "Animal Genetics",

issn = "0268-9146",

publisher = "Wiley-Blackwell",

number = "4",

}

Orr, N, Hill, EW, Gu, J, Govindarajan, P, Conroy, J, van Grevenhof, EM, Ducro, BJ, van Arendonk, JAM, Knaap, JH, van Weeren, PR, Machugh, DE, Ennis, S & Brama, PAJ 2013, 'Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10', Animal Genetics, vol. 44, no. 4, pp. 408-12. https://doi.org/10.1111/age.12016

TY - JOUR

T1 - Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10

AU - Orr, N

AU - Hill, E W

AU - Gu, J

AU - Govindarajan, P

AU - Conroy, J

AU - van Grevenhof, E M

AU - Ducro, B J

AU - van Arendonk, J A M

AU - Knaap, J H

AU - van Weeren, P R

AU - Machugh, D E

AU - Ennis, S

AU - Brama, P A J

PY - 2013/8

Y1 - 2013/8

N2 - Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10(-7) ) and chromosome 10 (BIEC2-121323; P = 2.62 × 10(-7) ).

AB - Equine osteochondrosis is a developmental joint disease that is a significant source of morbidity affecting multiple breeds of horse. The genetic variants underlying osteochondrosis susceptibility have not been established. Here, we describe the results of a genome-wide association study of osteochondrosis using 90 cases and 111 controls from a population of Dutch Warmblood horses. We report putative associations between osteochondrosis and loci on chromosome 3 (BIEC2-808543; P = 5.03 × 10(-7) ) and chromosome 10 (BIEC2-121323; P = 2.62 × 10(-7) ).

KW - Animals

KW - Breeding

KW - Chromosome Mapping

KW - Chromosomes, Mammalian

KW - Female

KW - Genetic Loci

KW - Genetic Predisposition to Disease

KW - Genome-Wide Association Study

KW - Genotype

KW - Haplotypes

KW - Horse Diseases

KW - Horses

KW - Joint Diseases

KW - Male

KW - Osteochondrosis

KW - Phenotype

KW - Polymorphism, Single Nucleotide

KW - Radiography

KW - Journal Article

U2 - 10.1111/age.12016

DO - 10.1111/age.12016

M3 - Article

C2 - 23278111

SN - 0268-9146

VL - 44

SP - 408

EP - 412

JO - Animal Genetics

JF - Animal Genetics

IS - 4

ER -

Genome-wide association study of osteochondrosis in the tarsocrural joint of Dutch Warmblood horses identifies susceptibility loci on chromosomes 3 and 10

Abstract

Keywords

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