Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

D.A. Tregouet; I.R. Konig; J. Erdmann; A. Munteanu; P.S. Braund; A.S. Hall; A. Grobhennig; [No Value] Linsel-Nitschke; C. Perret; M. DeSuremain; T. Meitinger; B.J. Wright; M. Preuss; S.G. Ball; C. Meisinger; C. Germain; Alun Evans

doi:10.1038/ng.314

Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

D.A. Tregouet
, I.R. Konig
, J. Erdmann
, A. Munteanu
, P.S. Braund
, A.S. Hall
, A. Grobhennig
, [No Value] Linsel-Nitschke
, C. Perret
, M. DeSuremain
, T. Meitinger
, B.J. Wright
, M. Preuss
, S.G. Ball
, C. Meisinger
, C. Germain
, Alun Evans

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

411 Citations (Scopus)

438 Downloads (Pure)

Abstract

We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

Original language	English
Pages (from-to)	283-285
Number of pages	3
Journal	Nature Genetics
Volume	41
Issue number	3
Early online date	08 Feb 2009
DOIs	https://doi.org/10.1038/ng.314
Publication status	Published - Mar 2009

ASJC Scopus subject areas

Genetics

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Tregouet, D. A., Konig, I. R., Erdmann, J., Munteanu, A., Braund, P. S., Hall, A. S., Grobhennig, A., Linsel-Nitschke, N. V., Perret, C., DeSuremain, M., Meitinger, T., Wright, B. J., Preuss, M., Ball, S. G., Meisinger, C., Germain, C., & Evans, A. (2009). Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease. Nature Genetics, 41(3), 283-285. https://doi.org/10.1038/ng.314

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title = "Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease",

abstract = "We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.",

author = "D.A. Tregouet and I.R. Konig and J. Erdmann and A. Munteanu and P.S. Braund and A.S. Hall and A. Grobhennig and Linsel-Nitschke, \{[No Value]\} and C. Perret and M. DeSuremain and T. Meitinger and B.J. Wright and M. Preuss and S.G. Ball and C. Meisinger and C. Germain and Alun Evans",

year = "2009",

month = mar,

doi = "10.1038/ng.314",

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Tregouet, DA, Konig, IR, Erdmann, J, Munteanu, A, Braund, PS, Hall, AS, Grobhennig, A, Linsel-Nitschke, NV, Perret, C, DeSuremain, M, Meitinger, T, Wright, BJ, Preuss, M, Ball, SG, Meisinger, C, Germain, C & Evans, A 2009, 'Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease', Nature Genetics, vol. 41, no. 3, pp. 283-285. https://doi.org/10.1038/ng.314

TY - JOUR

T1 - Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

AU - Tregouet, D.A.

AU - Konig, I.R.

AU - Erdmann, J.

AU - Munteanu, A.

AU - Braund, P.S.

AU - Hall, A.S.

AU - Grobhennig, A.

AU - Linsel-Nitschke, [No Value]

AU - Perret, C.

AU - DeSuremain, M.

AU - Meitinger, T.

AU - Wright, B.J.

AU - Preuss, M.

AU - Ball, S.G.

AU - Meisinger, C.

AU - Germain, C.

AU - Evans, Alun

PY - 2009/3

Y1 - 2009/3

N2 - We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

AB - We identify the SLC22A3-LPAL2-LPA gene cluster as a strong susceptibility locus for coronary artery disease (CAD) through a genome-wide haplotype association (GWHA) study. This locus was not identified from previous genome-wide association (GWA) studies focused on univariate analyses of SNPs. The proposed approach may have wide utility for analyzing GWA data for other complex traits.

U2 - 10.1038/ng.314

DO - 10.1038/ng.314

M3 - Article

SN - 1061-4036

VL - 41

SP - 283

EP - 285

JO - Nature Genetics

JF - Nature Genetics

IS - 3

ER -

Genome-wide haplotype association study identifies the SLC22A3-LPAL2-LPA gene cluster as a risk locus for coronary artery disease

Abstract

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