Genome-wide SNP association-based localization of a dwarfism gene in Friesian dwarf horses

N Orr, W Back, J Gu, P Leegwater, P Govindarajan, J Conroy, B Ducro, J A M Van Arendonk, D E MacHugh, S Ennis, E W Hill, P A J Brama

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)

Abstract

The recent completion of the horse genome and commercial availability of an equine SNP genotyping array has facilitated the mapping of disease genes. We report putative localization of the gene responsible for dwarfism, a trait in Friesian horses that is thought to have a recessive mode of inheritance, to a 2-MB region of chromosome 14 using just 10 affected animals and 10 controls. We successfully genotyped 34,429 SNPs that were tested for association with dwarfism using chi-square tests. The most significant SNP in our study, BIEC2-239376 (P(2df)=4.54 × 10(-5), P(rec)=7.74 × 10(-6)), is located close to a gene implicated in human dwarfism. Fine-mapping and resequencing analyses did not aid in further localization of the causative variant, and replication of our findings in independent sample sets will be necessary to confirm these results.

Original languageEnglish
Pages (from-to)2-7
Number of pages6
JournalAnimal Genetics
Volume41 Suppl 2
DOIs
Publication statusPublished - Dec 2010
Externally publishedYes

Keywords

  • Animals
  • Dwarfism
  • Genome-Wide Association Study
  • Horse Diseases
  • Horses
  • Polymorphism, Single Nucleotide
  • Journal Article
  • Research Support, Non-U.S. Gov't

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