Genomes of "phiKMV-like viruses" of Pseudomonas aeruginosa contain localized single-strand interruptions

Leonid Kulakov, V.N. Ksenzenko, M.G. Shlyapnikov, V.V. Kochetkov, Antonio Del Casale, Christopher Allen, Mike Larkin, P- Ceyssens, R. Lavigne

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)

Abstract

The "phiKMV-like viruses" comprise an important genus of T7 related phages infecting Pseudomonas aeruginosa. The genomes of these bacteriophages have localized single-strand interruptions (nicks), a distinguishing genomic trait previously thought to be unique for T5 related coliphages. Analysis of this feature in the newly sequenced phage fkF77 shows all four nicks to be localized on the non-coding DNA strand. They are present with high frequencies within the phage population and are introduced into the phage DNA at late stages of the lytic cycle. The general consensus sequence in the nicks (5'-CGACxxxxxCCTAoh pCTCCGG-3') was shown to be common among all phiKMV-related phages.
Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalVirology
Volume391
Issue number1
DOIs
Publication statusPublished - 15 Aug 2009

ASJC Scopus subject areas

  • Virology

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