Abstract
We examined virus genomic evolution in an immunocompromised patient with prolonged severe acute respiratory syndrome coronavirus 2 infection. Genomic sequencing revealed genetic variation during infection: 3 intrahost mutations and possible superinfection with a second strain of the virus. Prolonged infection in immunocompromised patients may lead to emergence of new virus variants.
| Original language | English |
|---|---|
| Pages (from-to) | 2499-2501 |
| Number of pages | 3 |
| Journal | Emerging Infectious Diseases |
| Volume | 27 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 01 Sept 2021 |
| Externally published | Yes |
Keywords
- 2019 novel coronavirus disease
- B-cell therapy
- coronavirus disease
- COVID-19
- immunocompromised
- respiratory infections
- SARS-CoV-2
- severe acute respiratory syndrome coronavirus 2
- superinfection
- virus evolution
- viruses
- zoonoses
ASJC Scopus subject areas
- Epidemiology
- Microbiology (medical)
- Infectious Diseases
Access to Document
- Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland
Copyright 2021 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.