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Genomic Evolution of SARS-CoV-2 Virus in Immunocompromised Patient, Ireland

  • Maureen Lynch
  • , Guerrino Macori
  • , Séamus Fanning
  • , Edel O'Regan
  • , Eoin Hunt
  • , Dermot O'Callaghan
  • , Brian McCullagh
  • , Cormac Jennings
  • , Anne Fortune

Research output: Contribution to journalArticlepeer-review

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Abstract

We examined virus genomic evolution in an immunocompromised patient with prolonged severe acute respiratory syndrome coronavirus 2 infection. Genomic sequencing revealed genetic variation during infection: 3 intrahost mutations and possible superinfection with a second strain of the virus. Prolonged infection in immunocompromised patients may lead to emergence of new virus variants.

Original languageEnglish
Pages (from-to)2499-2501
Number of pages3
JournalEmerging Infectious Diseases
Volume27
Issue number9
DOIs
Publication statusPublished - 01 Sept 2021
Externally publishedYes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

  1. SDG 3 - Good Health and Well-being
    SDG 3 Good Health and Well-being

Keywords

  • 2019 novel coronavirus disease
  • B-cell therapy
  • coronavirus disease
  • COVID-19
  • immunocompromised
  • respiratory infections
  • SARS-CoV-2
  • severe acute respiratory syndrome coronavirus 2
  • superinfection
  • virus evolution
  • viruses
  • zoonoses

ASJC Scopus subject areas

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

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