Genomic meningococcal load in the nasopharynx of children with meningococcal disease

Thomas W. Bourke; James P. McKenna; Peter V. Coyle; Derek J. Fairley; Michael D. Shields

doi:10.1097/INF.0000000000001079

Genomic meningococcal load in the nasopharynx of children with meningococcal disease

Thomas W. Bourke, James P. McKenna, Peter V. Coyle, Derek J. Fairley, Michael D. Shields

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Abstract

This study demonstrates the feasibility of using quantitative real time PCR to measure genomic bacterial load in the nasopharynx of children with invasive meningococcal disease and shows that these loads are exceptionally high (median 6.6 x 105 (Range 1.2 x 105 to 1.1 x 108) genome copies of Neisseria meningitidis per swab).

Original language	English
Pages (from-to)	577-579
Journal	The Pediatric Infectious Disease Journal
Volume	35
Issue number	5
Early online date	09 Feb 2016
DOIs	https://doi.org/10.1097/INF.0000000000001079
Publication status	Published - May 2016

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10.1097/INF.0000000000001079Licence: Unspecified

Genomic meningococcal load in the nasopharynx of children with meningococcal disease
© 2016, The Authors This is a non-final version of an article published in final form in Bourke, TW, McKenna, JP, Coyle, PV, Fairley, DJ & Shields, MD 2016, 'Genomic meningococcal load in the nasopharynx of children with meningococcal disease' The Pediatric Infectious Disease Journal, vol 35, no. 5, pp. 577-579., 10.1097/INF.0000000000001079
Accepted author manuscript, 775 KBLicence: Unspecified

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title = "Genomic meningococcal load in the nasopharynx of children with meningococcal disease",

abstract = "This study demonstrates the feasibility of using quantitative real time PCR to measure genomic bacterial load in the nasopharynx of children with invasive meningococcal disease and shows that these loads are exceptionally high (median 6.6 x 105 (Range 1.2 x 105 to 1.1 x 108) genome copies of Neisseria meningitidis per swab).",

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AB - This study demonstrates the feasibility of using quantitative real time PCR to measure genomic bacterial load in the nasopharynx of children with invasive meningococcal disease and shows that these loads are exceptionally high (median 6.6 x 105 (Range 1.2 x 105 to 1.1 x 108) genome copies of Neisseria meningitidis per swab).

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Genomic meningococcal load in the nasopharynx of children with meningococcal disease

Abstract

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