Genomic meningococcal load in the nasopharynx of children with meningococcal disease

Thomas W. Bourke; James P. McKenna; Peter V. Coyle; Derek J. Fairley; Michael D. Shields

doi:10.1097/INF.0000000000001079

Genomic meningococcal load in the nasopharynx of children with meningococcal disease

Thomas W. Bourke, James P. McKenna, Peter V. Coyle, Derek J. Fairley, Michael D. Shields

Research output: Contribution to journal › Article

258 Downloads (Pure)

Abstract

This study demonstrates the feasibility of using quantitative real time PCR to measure genomic bacterial load in the nasopharynx of children with invasive meningococcal disease and shows that these loads are exceptionally high (median 6.6 x 105 (Range 1.2 x 105 to 1.1 x 108) genome copies of Neisseria meningitidis per swab).

Original language	English
Pages (from-to)	577-579
Journal	The Pediatric Infectious Disease Journal
Volume	35
Issue number	5
Early online date	09 Feb 2016
DOIs	https://doi.org/10.1097/INF.0000000000001079
Publication status	Published - May 2016

Access to Document

10.1097/INF.0000000000001079Licence: Unspecified

Genomic meningococcal load in the nasopharynx of children with meningococcal disease
© 2016, The Authors This is a non-final version of an article published in final form in Bourke, TW, McKenna, JP, Coyle, PV, Fairley, DJ & Shields, MD 2016, 'Genomic meningococcal load in the nasopharynx of children with meningococcal disease' The Pediatric Infectious Disease Journal, vol 35, no. 5, pp. 577-579., 10.1097/INF.0000000000001079
Accepted author manuscript, 775 KBLicence: Unspecified

Fingerprint Dive into the research topics of 'Genomic meningococcal load in the nasopharynx of children with meningococcal disease'. Together they form a unique fingerprint.

Cite this

@article{3381df4dd7cf43be9b26b7629588050b,

title = "Genomic meningococcal load in the nasopharynx of children with meningococcal disease",

abstract = "This study demonstrates the feasibility of using quantitative real time PCR to measure genomic bacterial load in the nasopharynx of children with invasive meningococcal disease and shows that these loads are exceptionally high (median 6.6 x 105 (Range 1.2 x 105 to 1.1 x 108) genome copies of Neisseria meningitidis per swab).",

author = "Bourke, {Thomas W.} and McKenna, {James P.} and Coyle, {Peter V.} and Fairley, {Derek J.} and Shields, {Michael D.}",

year = "2016",

month = may,

doi = "10.1097/INF.0000000000001079",

language = "English",

volume = "35",

pages = "577--579",

journal = "The Pediatric Infectious Disease Journal",

issn = "0891-3668",

publisher = "Lippincott Williams and Wilkins",

number = "5",

}

TY - JOUR

T1 - Genomic meningococcal load in the nasopharynx of children with meningococcal disease

AU - Bourke, Thomas W.

AU - McKenna, James P.

AU - Coyle, Peter V.

AU - Fairley, Derek J.

AU - Shields, Michael D.

PY - 2016/5

Y1 - 2016/5

N2 - This study demonstrates the feasibility of using quantitative real time PCR to measure genomic bacterial load in the nasopharynx of children with invasive meningococcal disease and shows that these loads are exceptionally high (median 6.6 x 105 (Range 1.2 x 105 to 1.1 x 108) genome copies of Neisseria meningitidis per swab).

AB - This study demonstrates the feasibility of using quantitative real time PCR to measure genomic bacterial load in the nasopharynx of children with invasive meningococcal disease and shows that these loads are exceptionally high (median 6.6 x 105 (Range 1.2 x 105 to 1.1 x 108) genome copies of Neisseria meningitidis per swab).

U2 - 10.1097/INF.0000000000001079

DO - 10.1097/INF.0000000000001079

M3 - Article

C2 - 26862671

VL - 35

SP - 577

EP - 579

JO - The Pediatric Infectious Disease Journal

JF - The Pediatric Infectious Disease Journal

SN - 0891-3668

IS - 5

ER -