Genomics and the impact of new technologies on the management of colorectal cancer

D. Paul Harkin*

*Corresponding author for this work

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

High-throughput genomic technologies have the potential to have a major impact on preclinical and clinical drug development and the selection and stratification of patients in clinical trials. These technologies, which are at varying stages of commercialization, include array-based comparative genomic hybridization, single-nucleotide polymorphism arrays, and (the most mature example) expression-based arrays. One of the rate-limiting steps in the routine clinical application of expression array-based technology is the need for suitable clinical samples. One of the major challenges moving forward, therefore, relates to the ability to use formalin-fixed, paraffin-embedded--derived tissue in expression profiling-based approaches.
Original languageEnglish
Pages (from-to)988-991
Number of pages4
JournalThe Oncologist
Volume11
Issue number9
DOIs
Publication statusPublished - Oct 2006

Keywords

  • Array-based comparative genomic hybridization
  • Formalin-fixed paraffin-embedded
  • Genomics
  • Microarrays
  • RNA later
  • Single-nucleotide polymorphism arrays

ASJC Scopus subject areas

  • Cancer Research
  • Hematology

Fingerprint Dive into the research topics of 'Genomics and the impact of new technologies on the management of colorectal cancer'. Together they form a unique fingerprint.

Cite this