Glial and neuronal dysfunction in streptozotocin-induced diabetic rats

Vickie H Y Wong, Algis J Vingrys, Bang V Bui

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Neuronal dysfunction has been noted very soon after the induction of diabetes by streptozotocin injection in rats. It is not clear from anatomical evidence whether glial cell dysfunction accompanies the well-documented neuronal deficit. Here, we isolate the Müller cell driven slow-P3 component of the full-field electroretinogram and show that it is attenuated at 4 weeks following the onset of streptozotocin-hyperglycaemia. We also found a concurrent reduction in the sensitivity of the phototransduction cascade, as well as in the components of the electroretinogram known to indicate retinal ganglion cell and amacrine cell integrity. Our data support the idea that neuronal and Müller cell dysfunction occurs at the same time in streptozotocin-induced hyperglycaemia.
Original languageEnglish
Pages (from-to)42-50
Number of pages9
JournalJournal of Ocular Biology , Diseases, and Informatics
Issue number1-2
Publication statusPublished - Jun 2011


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