Global changes in gene expression by the opportunistic pathogen Burkholderia cenocepacia in response to internalization by murine macrophages

Jennifer S Tolman, Miguel A Valvano

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Burkholderia cenocepacia is an opportunistic pathogen causing life-threatening infections in patients with cystic fibrosis. The bacterium survives within macrophages by interfering with endocytic trafficking and delaying the maturation of the B. cenocepacia-containing phagosome. We hypothesize that B. cenocepacia undergoes changes in gene expression after internalization by macrophages, inducing genes involved in intracellular survival and host adaptation.
Original languageEnglish
Article number63
Pages (from-to)63
JournalBMC Genomics
Volume13
Issue number1
DOIs
Publication statusPublished - 09 Feb 2012

ASJC Scopus subject areas

  • Biotechnology
  • Genetics

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