Glucagon-like peptide-1 based therapies as a novel approach for chronic heart failure

David Grieve, Emma Robinson, Mitchel Tate, Brian Green, Barbara McDermott

Research output: Contribution to conferenceAbstract

Abstract

Glucagon-like peptide-1 (GLP-1) is an endogenous peptide hormone whose metabolic effects have been exploited for glycaemic control in diabetes, but which also exerts important cardiovascular actions. We have recently reported that the GLP-1 mimetic, exendin-4, exerts clear benefits post-myocardial infarction via specific effects on extracellular matrix remodelling which is dysregulated in the diabetic heart (Robinson E et al, Basic Res Cardiol 2015; 110: 20), and have now shown similar cardioprotective actions in experimental diabetes, which are mediated via direct effects on infiltrating macrophages (Tate M et al, Basic Res Cardiol 2016; 111: 1). Taken together with the apparent complexity of GLP-1 signalling and disappointing results of recent cardiovascular trials, our work strongly suggests that selective targeting of GLP-1 may be required in order to realise therapeutic benefit for both diabetic and non-diabetic heart failure patients. This is particularly important given the epidemic increase in the incidence of diabetes which is associated with a markedly enhanced susceptibility to cardiovascular stress.
Original languageEnglish
Publication statusAccepted - 06 Feb 2016
EventScottish Cardiovascular Forum -Annual Conference - Wellcome-Wolfson Research Institute, Belfast, United Kingdom
Duration: 06 Feb 201606 Feb 2016

Conference

ConferenceScottish Cardiovascular Forum -Annual Conference
CountryUnited Kingdom
CityBelfast
Period06/02/201606/02/2016

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    Grieve, D., Robinson, E., Tate, M., Green, B., & McDermott, B. (Accepted/In press). Glucagon-like peptide-1 based therapies as a novel approach for chronic heart failure. Abstract from Scottish Cardiovascular Forum -Annual Conference, Belfast, United Kingdom. http://www.scf.strath.ac.uk/