Glycopolymer Functionalization of Engineered Spider Silk Protein-based Materials for Improved Cell Adhesion

John G. Hardy; Andre Pfaff; Aldo Leal-Egana; Axel H. E. Mueller; Thomas R. Scheibel

doi:10.1002/mabi.201400020

Glycopolymer Functionalization of Engineered Spider Silk Protein-based Materials for Improved Cell Adhesion

John G. Hardy, Andre Pfaff, Aldo Leal-Egana, Axel H. E. Mueller^*, Thomas R. Scheibel

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

36 Citations (Scopus)

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Abstract

Silk protein-based materials are promising biomaterials for application as tissue scaffolds, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) and their functionalization with glycopolymers are described. The glycopolymers bind proteins found in the extracellular matrix, providing a biomimetic coating on the films that improves cell adhesion to the surfaces of engineered spider silk films. Such silk-based materials have potential as coatings for degradable implantable devices.

Original language	English
Pages (from-to)	936-942
Number of pages	7
Journal	Macromolecular Bioscience
Volume	14
Issue number	7
Early online date	02 Apr 2014
DOIs	https://doi.org/10.1002/mabi.201400020
Publication status	Published - Jul 2014
Externally published	Yes

Keywords

POLYMERS
RGD
BIOMATERIAL
SURFACES
COATINGS
collagen type 1 adhesin
Laminin

ASJC Scopus subject areas

Biomaterials
General Chemistry

Access to Document

10.1002/mabi.201400020

Glycopolymer Functionalization of Engineered Spider Silk Protein-based Materials for Improved Cell Adhesion
This is the accepted version of the following article: Hardy, J. G., Pfaff, A., Leal-Egaña, A., Müller, A. H. E. and Scheibel, T. R. (2014), Glycopolymer Functionalization of Engineered Spider Silk Protein-based Materials for Improved Cell Adhesion. Macromol. Biosci., 14: 936–942. doi: 10.1002/mabi.201400020, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/mabi.201400020/abstract;jsessionid=C0ADDD8E20B9165890A0AA37A98A68E2.f02t02.
Accepted author manuscript, 425 KB
Supplementary InformationAccepted author manuscript, 0.98 MB

Cite this

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title = "Glycopolymer Functionalization of Engineered Spider Silk Protein-based Materials for Improved Cell Adhesion",

abstract = "Silk protein-based materials are promising biomaterials for application as tissue scaffolds, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) and their functionalization with glycopolymers are described. The glycopolymers bind proteins found in the extracellular matrix, providing a biomimetic coating on the films that improves cell adhesion to the surfaces of engineered spider silk films. Such silk-based materials have potential as coatings for degradable implantable devices.",

keywords = "POLYMERS, RGD, BIOMATERIAL, SURFACES, COATINGS, collagen type 1 adhesin, Laminin",

author = "Hardy, {John G.} and Andre Pfaff and Aldo Leal-Egana and Mueller, {Axel H. E.} and Scheibel, {Thomas R.}",

year = "2014",

month = jul,

doi = "10.1002/mabi.201400020",

language = "English",

volume = "14",

pages = "936--942",

journal = "Macromolecular Bioscience",

issn = "1616-5187",

publisher = "Wiley-VCH Verlag",

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}

TY - JOUR

T1 - Glycopolymer Functionalization of Engineered Spider Silk Protein-based Materials for Improved Cell Adhesion

AU - Hardy, John G.

AU - Pfaff, Andre

AU - Leal-Egana, Aldo

AU - Mueller, Axel H. E.

AU - Scheibel, Thomas R.

PY - 2014/7

Y1 - 2014/7

N2 - Silk protein-based materials are promising biomaterials for application as tissue scaffolds, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) and their functionalization with glycopolymers are described. The glycopolymers bind proteins found in the extracellular matrix, providing a biomimetic coating on the films that improves cell adhesion to the surfaces of engineered spider silk films. Such silk-based materials have potential as coatings for degradable implantable devices.

AB - Silk protein-based materials are promising biomaterials for application as tissue scaffolds, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) and their functionalization with glycopolymers are described. The glycopolymers bind proteins found in the extracellular matrix, providing a biomimetic coating on the films that improves cell adhesion to the surfaces of engineered spider silk films. Such silk-based materials have potential as coatings for degradable implantable devices.

KW - POLYMERS

KW - RGD

KW - BIOMATERIAL

KW - SURFACES

KW - COATINGS

KW - collagen type 1 adhesin

KW - Laminin

U2 - 10.1002/mabi.201400020

DO - 10.1002/mabi.201400020

M3 - Article

SN - 1616-5187

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SP - 936

EP - 942

JO - Macromolecular Bioscience

JF - Macromolecular Bioscience

IS - 7

ER -

Glycopolymer Functionalization of Engineered Spider Silk Protein-based Materials for Improved Cell Adhesion

Abstract

Keywords

ASJC Scopus subject areas

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