Glycopolymer Functionalization of Engineered Spider Silk Protein-based Materials for Improved Cell Adhesion

John G. Hardy, Andre Pfaff, Aldo Leal-Egana, Axel H. E. Mueller*, Thomas R. Scheibel

*Corresponding author for this work

Research output: Contribution to journalArticle

19 Citations (Scopus)
247 Downloads (Pure)

Abstract

Silk protein-based materials are promising biomaterials for application as tissue scaffolds, due to their processability, biocompatibility, and biodegradability. The preparation of films composed of an engineered spider silk protein (eADF4(C16)) and their functionalization with glycopolymers are described. The glycopolymers bind proteins found in the extracellular matrix, providing a biomimetic coating on the films that improves cell adhesion to the surfaces of engineered spider silk films. Such silk-based materials have potential as coatings for degradable implantable devices.

Original languageEnglish
Pages (from-to)936-942
Number of pages7
JournalMacromolecular bioscience
Volume14
Issue number7
Early online date02 Apr 2014
DOIs
Publication statusPublished - Jul 2014
Externally publishedYes

Keywords

  • POLYMERS
  • RGD
  • BIOMATERIAL
  • SURFACES
  • COATINGS
  • collagen type 1 adhesin
  • Laminin

ASJC Scopus subject areas

  • Biomaterials
  • Chemistry(all)

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