Abstract
Glycosylation of low density lipoproteins obtained from 16 patients with Type 1 (insulin-dependent) diabetes and from 16 age-, sex-, and race-matched controls, was determined. The diabetic patients were normolipaemic and were in good or fair glycaemic control. Eleven patients performed home blood glucose monitoring. Glycosylation of low density lipoproteins in the diabetic patients was significantly higher (p less than 0.001) than in the control subjects, and was significantly correlated with haemoglobin A1c, (p less than 0.01), glycosylation of plasma proteins, (p less than 0.001), and mean home blood glucose, (p less than 0.01). This study confirms that, in diabetic patients, increased glycosylation of low density lipoprotein occurs to an extent which correlates closely with other commonly used indices of glycaemic control.
| Original language | English |
|---|---|
| Pages (from-to) | 685-9 |
| Number of pages | 5 |
| Journal | Diabetologia |
| Volume | 29 |
| Issue number | 10 |
| Publication status | Published - Oct 1986 |
Keywords
- Adult
- Blood Glucose
- Blood Proteins
- Cholesterol
- Diabetes Mellitus, Type 1
- Female
- Humans
- Lipoproteins, LDL
- Male
- Middle Aged
- Patient Compliance
- Reference Values
- Triglycerides
