Gold glyconanoparticles coupled to listeriolysin O 91-99 peptide serve as adjuvant therapy against melanoma

Ricardo Calderon-Gonzalez, Hector Teran-Navarro, Isabel Garcia, Marco Marradi, David Salcines-Cuevas, Sonsoles Yañez-Diaz, Adriana Solis-Angulo, Elisabet Frande-Cabanes, Maria del Carmen Fariñas, Almudena Garcia-Castaño, Jose Javier Gomez-Roman, Soledad Penades, Fernando Rivera, Javier Freire, Carmen Alvarez-Dominguez

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9 Citations (Scopus)

Abstract

Dendritic cell-based (DC-based) vaccines are promising immunotherapies for cancer. However, several factors, such as the lack of efficient targeted delivery and the sources and types of DCs, have limited the efficacy of DCs and their clinical potential. We propose an alternative nanotechnology-based vaccine platform with antibacterial prophylactic abilities that uses gold glyconanoparticles coupled to listeriolysin O 91-99 peptide (GNP-LLO91-99), which acts as a novel adjuvant for cancer therapy. GNP-LLO91-99, when used to vaccinate mice, exhibited dual antitumour activities, namely, the inhibition of tumour migration and growth and adjuvant activity for recruiting and activating DCs, including those from melanoma patients. GNP-LLO91-99 nanoparticles caused tumour apoptosis and induced antigen- and melanoma-specific cytotoxic Th1 responses (P ≤ 0.5). We propose this adjuvant nanotherapy for preventing the progression of the first stages of melanoma.
Original languageEnglish
Pages (from-to)10721-10732
JournalNanoscale
Volume9
Issue number30
DOIs
Publication statusPublished - 03 Aug 2017
Externally publishedYes

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    Calderon-Gonzalez, R., Teran-Navarro, H., Garcia, I., Marradi, M., Salcines-Cuevas, D., Yañez-Diaz, S., Solis-Angulo, A., Frande-Cabanes, E., Fariñas, M. D. C., Garcia-Castaño, A., Gomez-Roman, J. J., Penades, S., Rivera, F., Freire, J., & Alvarez-Dominguez, C. (2017). Gold glyconanoparticles coupled to listeriolysin O 91-99 peptide serve as adjuvant therapy against melanoma. Nanoscale, 9(30), 10721-10732. https://doi.org/10.1039/c7nr02494k