Gold nanoparticle surface functionalization: a necessary requirement in the development of novel nanotherapeutics

James R. Nicol, Dorian Dixon, Jonathan A. Coulter

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)
2206 Downloads (Pure)

Abstract

With several gold nanoparticle-based therapies currently undergoing clinical trials, these treatments may soon be in the clinic as novel anticancer agents. Gold nanoparticles are the subject of a wide ranging international research effort with preclinical studies underway for multiple applications including photoablation, diagnostic imaging, radiosensitization and multifunctional drug-delivery vehicles. These applications require an increasingly complex level of surface modification in order to achieve efficacy and limit off-target toxicity. This review will discuss the main obstacles in relation to surface functionalization and the chemical approaches commonly utilized. Finally, we review a range of recent preclinical studies that aim to advance gold nanoparticle treatments toward the clinic.
Original languageEnglish
Pages (from-to)1315-1326
Number of pages12
JournalNanomedicine
Volume10
Issue number8
DOIs
Publication statusPublished - 2015

Fingerprint

Dive into the research topics of 'Gold nanoparticle surface functionalization: a necessary requirement in the development of novel nanotherapeutics'. Together they form a unique fingerprint.

Cite this