Gold nanoparticle surface functionalization: mixed monolayer versus hetero bifunctional peg linker

Emma Harrison, Jonathan A Coulter, Dorian Dixon

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To create a clinically relevant gold nanoparticle (AuNP) treatment, the surface must be functionalized with multiple ligands such as drugs, antifouling agents and targeting moieties. However, attaching several ligands of differing chemistries and lengths, while ensuring they all retain their biological functionality remains a challenge. This review compares the two most widely employed methods of surface co-functionalization, namely mixed monolayers and hetero-bifunctional linkers. While there are numerous in vitro studies successfully utilizing both surface arrangements, there is little consensus regarding their relative merits. Animal and preclinical studies have demonstrated the effectiveness of mixed monolayer functionalization and while some promising in vitro results have been reported for PEG linker capped AuNPs, any potential benefits of the approach are not yet fully understood.

Original languageEnglish
Pages (from-to)851-865
Number of pages15
JournalNanomedicine
Volume11
Issue number7
DOIs
Publication statusPublished - Apr 2016

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