Gray matter volume in the right angular gyrus is associated with differential patterns of multisensory integration with aging

Rebecca J. Hirst; Robert Whelan; Rory Boyle; Annalisa  Setti; Silvin Knight; John O'Connor; Wilby Williamson; Jason McMorrow; Andrew J. Fagan; James F. Meaney; Rose Anne Kenny; Céline De Looze; Fiona N. Newell

doi:10.1016/j.neurobiolaging.2020.12.004

Gray matter volume in the right angular gyrus is associated with differential patterns of multisensory integration with aging

Rebecca J. Hirst^*, Robert Whelan, Rory Boyle, Annalisa Setti, Silvin Knight, John O'Connor, Wilby Williamson, Jason McMorrow, Andrew J. Fagan, James F. Meaney, Rose Anne Kenny, Céline De Looze, Fiona N. Newell

^*Corresponding author for this work

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Abstract

Multisensory perception might provide an important marker of brain function in aging. However, the cortical structures supporting multisensory perception in aging are poorly understood. In this study, we compared regional gray matter volume in a group of middle-aged (n = 101; 49–64 years) and older (n = 116; 71–87 years) adults from The Irish Longitudinal Study on Aging using voxel-based morphometry. Participants completed a measure of multisensory integration, the sound-induced flash illusion, and were grouped as per their illusion susceptibility. A significant interaction was observed in the right angular gyrus; in the middle-aged group, larger gray matter volume corresponded to stronger illusion perception while in older adults larger gray matter corresponded to less illusion susceptibility. This interaction remained significant even when controlling for a range of demographic, sensory, cognitive, and health variables. These findings show that multisensory integration is associated with specific structural differences in the aging brain and highlight the angular gyrus as a possible “cross-modal hub” associated with age-related change in multisensory perception.

Original language	English
Pages (from-to)	83-90
Journal	Neurobiology of Aging
Volume	100
Early online date	25 Dec 2020
DOIs	https://doi.org/10.1016/j.neurobiolaging.2020.12.004
Publication status	Published - 01 Apr 2021
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the Health Research Board (HRB), Ireland ; Grant references ILP-PHR-2017-014 and HRA-PHR-2014-667 . Funding for The Irish Longitudinal Study on Aging (TILDA) is provided by the Irish Government, the Health Research Board (HRB), The Atlantic Philanthropies, and the Irish Life PLC. Funders played no role in the design, execution, analysis, interpretation of data, or writing of this research. The authors would like to acknowledge the continued commitment and cooperation of the TILDA participants and research team. MRI data collection was supported by the National Center for Advanced Medical Imaging (CAMI).

Publisher Copyright:
© 2020 The Author(s)

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

Keywords

Aging
Audio-visual
Gray matter volume
Multisensory
Sound-Induced Flash illusion
Voxel-based morphometry

ASJC Scopus subject areas

Neuroscience(all)
Ageing
Clinical Neurology
Developmental Biology
Geriatrics and Gerontology

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Gray matter volume in the right angular gyrus is associated with differential patterns of multisensory integration with agingFinal published version, 489 KBLicence: CC BY-NC-ND

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Hirst, R. J., Whelan, R., Boyle, R., Setti, A., Knight, S., O'Connor, J., Williamson, W., McMorrow, J., Fagan, A. J., Meaney, J. F., Kenny, R. A., De Looze, C., & Newell, F. N. (2021). Gray matter volume in the right angular gyrus is associated with differential patterns of multisensory integration with aging. Neurobiology of Aging, 100, 83-90. https://doi.org/10.1016/j.neurobiolaging.2020.12.004

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abstract = "Multisensory perception might provide an important marker of brain function in aging. However, the cortical structures supporting multisensory perception in aging are poorly understood. In this study, we compared regional gray matter volume in a group of middle-aged (n = 101; 49–64 years) and older (n = 116; 71–87 years) adults from The Irish Longitudinal Study on Aging using voxel-based morphometry. Participants completed a measure of multisensory integration, the sound-induced flash illusion, and were grouped as per their illusion susceptibility. A significant interaction was observed in the right angular gyrus; in the middle-aged group, larger gray matter volume corresponded to stronger illusion perception while in older adults larger gray matter corresponded to less illusion susceptibility. This interaction remained significant even when controlling for a range of demographic, sensory, cognitive, and health variables. These findings show that multisensory integration is associated with specific structural differences in the aging brain and highlight the angular gyrus as a possible “cross-modal hub” associated with age-related change in multisensory perception.",

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note = "Funding Information: This work was supported by the Health Research Board (HRB), Ireland ; Grant references ILP-PHR-2017-014 and HRA-PHR-2014-667 . Funding for The Irish Longitudinal Study on Aging (TILDA) is provided by the Irish Government, the Health Research Board (HRB), The Atlantic Philanthropies, and the Irish Life PLC. Funders played no role in the design, execution, analysis, interpretation of data, or writing of this research. The authors would like to acknowledge the continued commitment and cooperation of the TILDA participants and research team. MRI data collection was supported by the National Center for Advanced Medical Imaging (CAMI). Publisher Copyright: {\textcopyright} 2020 The Author(s) Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",

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Hirst, RJ, Whelan, R, Boyle, R, Setti, A, Knight, S, O'Connor, J, Williamson, W, McMorrow, J, Fagan, AJ, Meaney, JF, Kenny, RA, De Looze, C & Newell, FN 2021, 'Gray matter volume in the right angular gyrus is associated with differential patterns of multisensory integration with aging', Neurobiology of Aging, vol. 100, pp. 83-90. https://doi.org/10.1016/j.neurobiolaging.2020.12.004

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AU - Hirst, Rebecca J.

AU - Whelan, Robert

AU - Boyle, Rory

AU - Setti, Annalisa

AU - Knight, Silvin

AU - O'Connor, John

AU - Williamson, Wilby

AU - McMorrow, Jason

AU - Fagan, Andrew J.

AU - Meaney, James F.

AU - Kenny, Rose Anne

AU - De Looze, Céline

AU - Newell, Fiona N.

N1 - Funding Information: This work was supported by the Health Research Board (HRB), Ireland ; Grant references ILP-PHR-2017-014 and HRA-PHR-2014-667 . Funding for The Irish Longitudinal Study on Aging (TILDA) is provided by the Irish Government, the Health Research Board (HRB), The Atlantic Philanthropies, and the Irish Life PLC. Funders played no role in the design, execution, analysis, interpretation of data, or writing of this research. The authors would like to acknowledge the continued commitment and cooperation of the TILDA participants and research team. MRI data collection was supported by the National Center for Advanced Medical Imaging (CAMI). Publisher Copyright: © 2020 The Author(s) Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/4/1

Y1 - 2021/4/1

N2 - Multisensory perception might provide an important marker of brain function in aging. However, the cortical structures supporting multisensory perception in aging are poorly understood. In this study, we compared regional gray matter volume in a group of middle-aged (n = 101; 49–64 years) and older (n = 116; 71–87 years) adults from The Irish Longitudinal Study on Aging using voxel-based morphometry. Participants completed a measure of multisensory integration, the sound-induced flash illusion, and were grouped as per their illusion susceptibility. A significant interaction was observed in the right angular gyrus; in the middle-aged group, larger gray matter volume corresponded to stronger illusion perception while in older adults larger gray matter corresponded to less illusion susceptibility. This interaction remained significant even when controlling for a range of demographic, sensory, cognitive, and health variables. These findings show that multisensory integration is associated with specific structural differences in the aging brain and highlight the angular gyrus as a possible “cross-modal hub” associated with age-related change in multisensory perception.

AB - Multisensory perception might provide an important marker of brain function in aging. However, the cortical structures supporting multisensory perception in aging are poorly understood. In this study, we compared regional gray matter volume in a group of middle-aged (n = 101; 49–64 years) and older (n = 116; 71–87 years) adults from The Irish Longitudinal Study on Aging using voxel-based morphometry. Participants completed a measure of multisensory integration, the sound-induced flash illusion, and were grouped as per their illusion susceptibility. A significant interaction was observed in the right angular gyrus; in the middle-aged group, larger gray matter volume corresponded to stronger illusion perception while in older adults larger gray matter corresponded to less illusion susceptibility. This interaction remained significant even when controlling for a range of demographic, sensory, cognitive, and health variables. These findings show that multisensory integration is associated with specific structural differences in the aging brain and highlight the angular gyrus as a possible “cross-modal hub” associated with age-related change in multisensory perception.

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KW - Audio-visual

KW - Gray matter volume

KW - Multisensory

KW - Sound-Induced Flash illusion

KW - Voxel-based morphometry

U2 - 10.1016/j.neurobiolaging.2020.12.004

DO - 10.1016/j.neurobiolaging.2020.12.004

M3 - Article

AN - SCOPUS:85099836784

VL - 100

SP - 83

EP - 90

JO - Neurobiology of Aging

JF - Neurobiology of Aging

SN - 0197-4580

ER -

Gray matter volume in the right angular gyrus is associated with differential patterns of multisensory integration with aging

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

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