Growth Inhibitory Activity of Extracted Material and Isolated Compounds from the Fruits of Kigelia pinnata

Catherine Higgins, Thomas Bell, Z. Delbederi, S. Feutren-Burton, B. McClean, Colin O'Dowd, W. Watters, P. Armstrong, David Waugh, Hendrik Van Den Berg

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

A study of the components of the fruits of Kigelia pinnata was undertaken to identify compounds with potential growth inhibitory activity against human melanoma cells, since extracts from the fruits of this plant have been described in traditional medicine to have application in the treatment of skin cancer and other skin ailments. A bioactivity-guided fractionation process yielded a number of crude fractions, which demonstrated cytotoxicity in vitro against human melanoma cells. Compounds isolated and identified included the isocoumarins, demethylkigelin (1) and kigelin 2), fatty acids, oleic (3) and heneicosanoic acids (4), the furonaphthoquinone, 2-(1-hydroxyethyl)-naphtho[2,3-b]furan-4,9-dione (5), and ferulic acid (6). A number of structurally related synthetic compounds were also tested using the MTT assay. The most potent series of these compounds, the furonaphthoquinones, also demonstrated a cytotoxic effect in two human breast cancer cell lines tested.
Original languageEnglish
Pages (from-to)1840-1846
Number of pages7
JournalPlanta Medica
Volume76
Issue number16
DOIs
Publication statusPublished - 2010

ASJC Scopus subject areas

  • Complementary and alternative medicine
  • Molecular Medicine
  • Organic Chemistry
  • Analytical Chemistry
  • Pharmaceutical Science
  • Pharmacology
  • Drug Discovery

Fingerprint Dive into the research topics of 'Growth Inhibitory Activity of Extracted Material and Isolated Compounds from the Fruits of Kigelia pinnata'. Together they form a unique fingerprint.

  • Cite this

    Higgins, C., Bell, T., Delbederi, Z., Feutren-Burton, S., McClean, B., O'Dowd, C., Watters, W., Armstrong, P., Waugh, D., & Van Den Berg, H. (2010). Growth Inhibitory Activity of Extracted Material and Isolated Compounds from the Fruits of Kigelia pinnata. Planta Medica, 76(16), 1840-1846. https://doi.org/10.1055/s-0030-1250046