Growth of human B cell colonies from peripheral blood of patients with systemic lupus erythematosus

A C Fay, S Price, A Trudgett, J D McCrea, M Haire, M W Boyd, T A McNeill

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Abstract

Human B cell colonies were grown from peripheral blood of 12 patients with systemic lupus erythematosus (SLE) and from 12 healthy control subjects. The SLE group showed a large increase (p less than 0.001) in the number of colony forming cells (CFC) present in peripheral blood as compared with controls. The CFC were of the pre-B cell type. There was also a loss of OKT8+ cell inhibition of B cell colony growth in the SLE group compared with control subjects.
Original languageEnglish
Pages (from-to)95-100
Number of pages6
JournalAnnals of the Rheumatic Diseases
Volume45
Issue number2
Publication statusPublished - Feb 1986

Keywords

  • Adult
  • Aged
  • B-Lymphocytes
  • Cells, Cultured
  • Female
  • Fluorescent Antibody Technique
  • Humans
  • Lupus Erythematosus, Systemic
  • Middle Aged
  • Stem Cells
  • T-Lymphocytes

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    Fay, A. C., Price, S., Trudgett, A., McCrea, J. D., Haire, M., Boyd, M. W., & McNeill, T. A. (1986). Growth of human B cell colonies from peripheral blood of patients with systemic lupus erythematosus. Annals of the Rheumatic Diseases, 45(2), 95-100.