Human B cell colonies were grown from peripheral blood of 12 patients with systemic lupus erythematosus (SLE) and from 12 healthy control subjects. The SLE group showed a large increase (p less than 0.001) in the number of colony forming cells (CFC) present in peripheral blood as compared with controls. The CFC were of the pre-B cell type. There was also a loss of OKT8+ cell inhibition of B cell colony growth in the SLE group compared with control subjects.
|Number of pages||6|
|Journal||Annals of the Rheumatic Diseases|
|Publication status||Published - Feb 1986|
- Cells, Cultured
- Fluorescent Antibody Technique
- Lupus Erythematosus, Systemic
- Middle Aged
- Stem Cells
Fay, A. C., Price, S., Trudgett, A., McCrea, J. D., Haire, M., Boyd, M. W., & McNeill, T. A. (1986). Growth of human B cell colonies from peripheral blood of patients with systemic lupus erythematosus. Annals of the Rheumatic Diseases, 45(2), 95-100.