Growth of human B cell colonies from peripheral blood of patients with systemic lupus erythematosus

A C Fay; S Price; A Trudgett; J D McCrea; M Haire; M W Boyd; T A McNeill

Growth of human B cell colonies from peripheral blood of patients with systemic lupus erythematosus

A C Fay, S Price, A Trudgett, J D McCrea, M Haire, M W Boyd, T A McNeill

Research output: Contribution to journal › Article › peer-review

Abstract

Human B cell colonies were grown from peripheral blood of 12 patients with systemic lupus erythematosus (SLE) and from 12 healthy control subjects. The SLE group showed a large increase (p less than 0.001) in the number of colony forming cells (CFC) present in peripheral blood as compared with controls. The CFC were of the pre-B cell type. There was also a loss of OKT8+ cell inhibition of B cell colony growth in the SLE group compared with control subjects.

Original language	English
Pages (from-to)	95-100
Number of pages	6
Journal	Annals of the Rheumatic Diseases
Volume	45
Issue number	2
Publication status	Published - Feb 1986

Keywords

Adult
Aged
B-Lymphocytes
Cells, Cultured
Female
Fluorescent Antibody Technique
Humans
Lupus Erythematosus, Systemic
Middle Aged
Stem Cells
T-Lymphocytes

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{cda4883c224c4d86a67ecc6ec2faf166,

title = "Growth of human B cell colonies from peripheral blood of patients with systemic lupus erythematosus",

abstract = "Human B cell colonies were grown from peripheral blood of 12 patients with systemic lupus erythematosus (SLE) and from 12 healthy control subjects. The SLE group showed a large increase (p less than 0.001) in the number of colony forming cells (CFC) present in peripheral blood as compared with controls. The CFC were of the pre-B cell type. There was also a loss of OKT8+ cell inhibition of B cell colony growth in the SLE group compared with control subjects.",

keywords = "Adult, Aged, B-Lymphocytes, Cells, Cultured, Female, Fluorescent Antibody Technique, Humans, Lupus Erythematosus, Systemic, Middle Aged, Stem Cells, T-Lymphocytes",

author = "Fay, {A C} and S Price and A Trudgett and McCrea, {J D} and M Haire and Boyd, {M W} and McNeill, {T A}",

year = "1986",

month = feb,

language = "English",

volume = "45",

pages = "95--100",

journal = "Annals of the Rheumatic Diseases",

issn = "0003-4967",

publisher = "BMJ Publishing Group",

number = "2",

}

TY - JOUR

T1 - Growth of human B cell colonies from peripheral blood of patients with systemic lupus erythematosus

AU - Fay, A C

AU - Price, S

AU - Trudgett, A

AU - McCrea, J D

AU - Haire, M

AU - Boyd, M W

AU - McNeill, T A

PY - 1986/2

Y1 - 1986/2

N2 - Human B cell colonies were grown from peripheral blood of 12 patients with systemic lupus erythematosus (SLE) and from 12 healthy control subjects. The SLE group showed a large increase (p less than 0.001) in the number of colony forming cells (CFC) present in peripheral blood as compared with controls. The CFC were of the pre-B cell type. There was also a loss of OKT8+ cell inhibition of B cell colony growth in the SLE group compared with control subjects.

AB - Human B cell colonies were grown from peripheral blood of 12 patients with systemic lupus erythematosus (SLE) and from 12 healthy control subjects. The SLE group showed a large increase (p less than 0.001) in the number of colony forming cells (CFC) present in peripheral blood as compared with controls. The CFC were of the pre-B cell type. There was also a loss of OKT8+ cell inhibition of B cell colony growth in the SLE group compared with control subjects.

KW - Adult

KW - Aged

KW - B-Lymphocytes

KW - Cells, Cultured

KW - Female

KW - Fluorescent Antibody Technique

KW - Humans

KW - Lupus Erythematosus, Systemic

KW - Middle Aged

KW - Stem Cells

KW - T-Lymphocytes

M3 - Article

C2 - 3511863

SN - 0003-4967

VL - 45

SP - 95

EP - 100

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

IS - 2

ER -

Growth of human B cell colonies from peripheral blood of patients with systemic lupus erythematosus

Abstract

Keywords

UN SDGs

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