Gut Check Time: Antibiotic Delivery Strategies to Reduce Antimicrobial Resistance

Stephen A. Kelly, Aoife M. Rodgers, Séamus C. O'Brien, Ryan F. Donnelly, Brendan F. Gilmore*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

9 Citations (Scopus)

Abstract

Antimicrobial resistance (AMR) has developed into a huge threat to global health, and reducing it is an urgent priority for public health authorities. The importance of a healthy and balanced gut microbiome has been identified as a key protective factor against AMR development, but this can be significantly affected by antibiotic therapy, resulting in dysbiosis and reduction of taxonomic richness. The way in which antibiotics are administered could form an important part of future antimicrobial stewardship strategies, where drug delivery is ideally placed to play a key role in the fight against AMR. This review focuses on drug delivery strategies for antibiotic administration, including avoidance of the gut microbiome and targeted delivery approaches, which may reduce AMR.

Original languageEnglish
JournalTrends in Biotechnology
Early online date19 Nov 2019
DOIs
Publication statusEarly online date - 19 Nov 2019

Keywords

  • antibiotic delivery
  • antimicrobial resistance
  • dysbiosis
  • gut

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering

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