Gut hormone GPCRs: structure, function, drug discovery

Arnau Cordomí, Daniel Fourmy, Irina G Tikhonova

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)
397 Downloads (Pure)


Crystallization and determination of the high resolution three-dimensional structure of the β2-adrenergic receptor in 2007 was followed by structure elucidation of a number of other receptors, including those for neurotensin and glucagon. These major advances foster the understanding of structure-activity relationship of these receptors and structure-based rational design of new ligands having more predictable activity. At present, structure determination of gut hormone receptors in complex with their ligands (natural, synthetic) and interacting signalling proteins, for example, G-proteins, arrestins, represents a challenge which promises to revolutionize gut hormone endocrinonology.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalCurrent Opinion in Pharmacology
Early online date16 Sep 2016
Publication statusPublished - Dec 2016


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