GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence

Karen M Eny, Helen L Lutgers, John Maynard, Barbara E K Klein, Kristine E Lee, Gil Atzmon, Vincent M Monnier, Jana V van Vliet-Ostaptchouk, Reindert Graaff, Pim van der Harst, Harold Snieder, Melanie M van der Klauw, David R Sell, S Mohsen Hosseini, Patricia A Cleary, Barbara H Braffett, Trevor J Orchard, Timothy J Lyons, Kerri Howard, Ronald KleinJill P Crandall, Nir Barzilai, Sofiya Milman, Danny Ben-Avraham, Bruce H R Wolffenbuttel, Andrew D Paterson, LifeLines Cohort Study Group

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Skin fluorescence (SF) is a non-invasive marker of AGEs and is associated with the long-term complications of diabetes. SF increases with age and is also greater among individuals with diabetes. A familial correlation of SF suggests that genetics may play a role. We therefore performed parallel genome-wide association studies of SF in two cohorts.
Original languageEnglish
JournalDiabetologia
DOIs
Publication statusPublished - 17 Jun 2014

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