GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence

Karen M Eny; Helen L Lutgers; John Maynard; Barbara E K Klein; Kristine E Lee; Gil Atzmon; Vincent M Monnier; Jana V van Vliet-Ostaptchouk; Reindert Graaff; Pim van der Harst; Harold Snieder; Melanie M van der Klauw; David R Sell; S Mohsen Hosseini; Patricia A Cleary; Barbara H Braffett; Trevor J Orchard; Timothy J Lyons; Kerri Howard; Ronald Klein; Jill P Crandall; Nir Barzilai; Sofiya Milman; Danny Ben-Avraham; Bruce H R Wolffenbuttel; Andrew D Paterson; LifeLines Cohort Study Group

doi:10.1007/s00125-014-3286-9

GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence

Karen M Eny, Helen L Lutgers, John Maynard, Barbara E K Klein, Kristine E Lee, Gil Atzmon, Vincent M Monnier, Jana V van Vliet-Ostaptchouk, Reindert Graaff, Pim van der Harst, Harold Snieder, Melanie M van der Klauw, David R Sell, S Mohsen Hosseini, Patricia A Cleary, Barbara H Braffett, Trevor J Orchard, Timothy J Lyons, Kerri Howard, Ronald KleinJill P Crandall, Nir Barzilai, Sofiya Milman, Danny Ben-Avraham, Bruce H R Wolffenbuttel, Andrew D Paterson, LifeLines Cohort Study Group

Research output: Contribution to journal › Article › peer-review

30 Citations (Scopus)

Abstract

Skin fluorescence (SF) is a non-invasive marker of AGEs and is associated with the long-term complications of diabetes. SF increases with age and is also greater among individuals with diabetes. A familial correlation of SF suggests that genetics may play a role. We therefore performed parallel genome-wide association studies of SF in two cohorts.

Original language	English
Journal	Diabetologia
DOIs	https://doi.org/10.1007/s00125-014-3286-9
Publication status	Published - 17 Jun 2014

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Eny, K. M., Lutgers, H. L., Maynard, J., Klein, B. E. K., Lee, K. E., Atzmon, G., Monnier, V. M., van Vliet-Ostaptchouk, J. V., Graaff, R., van der Harst, P., Snieder, H., van der Klauw, M. M., Sell, D. R., Hosseini, S. M., Cleary, P. A., Braffett, B. H., Orchard, T. J., Lyons, T. J., Howard, K., ... LifeLines Cohort Study Group (2014). GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence. Diabetologia. https://doi.org/10.1007/s00125-014-3286-9

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title = "GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence",

abstract = "Skin fluorescence (SF) is a non-invasive marker of AGEs and is associated with the long-term complications of diabetes. SF increases with age and is also greater among individuals with diabetes. A familial correlation of SF suggests that genetics may play a role. We therefore performed parallel genome-wide association studies of SF in two cohorts.",

author = "Eny, {Karen M} and Lutgers, {Helen L} and John Maynard and Klein, {Barbara E K} and Lee, {Kristine E} and Gil Atzmon and Monnier, {Vincent M} and {van Vliet-Ostaptchouk}, {Jana V} and Reindert Graaff and {van der Harst}, Pim and Harold Snieder and {van der Klauw}, {Melanie M} and Sell, {David R} and Hosseini, {S Mohsen} and Cleary, {Patricia A} and Braffett, {Barbara H} and Orchard, {Trevor J} and Lyons, {Timothy J} and Kerri Howard and Ronald Klein and Crandall, {Jill P} and Nir Barzilai and Sofiya Milman and Danny Ben-Avraham and Wolffenbuttel, {Bruce H R} and Paterson, {Andrew D} and {LifeLines Cohort Study Group}",

year = "2014",

month = jun,

day = "17",

doi = "10.1007/s00125-014-3286-9",

language = "English",

journal = "Diabetologia",

issn = "1432-0428",

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Eny, KM, Lutgers, HL, Maynard, J, Klein, BEK, Lee, KE, Atzmon, G, Monnier, VM, van Vliet-Ostaptchouk, JV, Graaff, R, van der Harst, P, Snieder, H, van der Klauw, MM, Sell, DR, Hosseini, SM, Cleary, PA, Braffett, BH, Orchard, TJ, Lyons, TJ, Howard, K, Klein, R, Crandall, JP, Barzilai, N, Milman, S, Ben-Avraham, D, Wolffenbuttel, BHR, Paterson, AD & LifeLines Cohort Study Group 2014, 'GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence', Diabetologia. https://doi.org/10.1007/s00125-014-3286-9

TY - JOUR

T1 - GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence

AU - Eny, Karen M

AU - Lutgers, Helen L

AU - Maynard, John

AU - Klein, Barbara E K

AU - Lee, Kristine E

AU - Atzmon, Gil

AU - Monnier, Vincent M

AU - van Vliet-Ostaptchouk, Jana V

AU - Graaff, Reindert

AU - van der Harst, Pim

AU - Snieder, Harold

AU - van der Klauw, Melanie M

AU - Sell, David R

AU - Hosseini, S Mohsen

AU - Cleary, Patricia A

AU - Braffett, Barbara H

AU - Orchard, Trevor J

AU - Lyons, Timothy J

AU - Howard, Kerri

AU - Klein, Ronald

AU - Crandall, Jill P

AU - Barzilai, Nir

AU - Milman, Sofiya

AU - Ben-Avraham, Danny

AU - Wolffenbuttel, Bruce H R

AU - Paterson, Andrew D

AU - LifeLines Cohort Study Group

PY - 2014/6/17

Y1 - 2014/6/17

N2 - Skin fluorescence (SF) is a non-invasive marker of AGEs and is associated with the long-term complications of diabetes. SF increases with age and is also greater among individuals with diabetes. A familial correlation of SF suggests that genetics may play a role. We therefore performed parallel genome-wide association studies of SF in two cohorts.

AB - Skin fluorescence (SF) is a non-invasive marker of AGEs and is associated with the long-term complications of diabetes. SF increases with age and is also greater among individuals with diabetes. A familial correlation of SF suggests that genetics may play a role. We therefore performed parallel genome-wide association studies of SF in two cohorts.

U2 - 10.1007/s00125-014-3286-9

DO - 10.1007/s00125-014-3286-9

M3 - Article

C2 - 24934506

SN - 1432-0428

JO - Diabetologia

JF - Diabetologia

ER -

GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence

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