GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence

Karen M Eny, Helen L Lutgers, John Maynard, Barbara E K Klein, Kristine E Lee, Gil Atzmon, Vincent M Monnier, Jana V van Vliet-Ostaptchouk, Reindert Graaff, Pim van der Harst, Harold Snieder, Melanie M van der Klauw, David R Sell, S Mohsen Hosseini, Patricia A Cleary, Barbara H Braffett, Trevor J Orchard, Timothy J Lyons, Kerri Howard, Ronald KleinJill P Crandall, Nir Barzilai, Sofiya Milman, Danny Ben-Avraham, Bruce H R Wolffenbuttel, Andrew D Paterson, LifeLines Cohort Study Group

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22 Citations (Scopus)

Abstract

Skin fluorescence (SF) is a non-invasive marker of AGEs and is associated with the long-term complications of diabetes. SF increases with age and is also greater among individuals with diabetes. A familial correlation of SF suggests that genetics may play a role. We therefore performed parallel genome-wide association studies of SF in two cohorts.
Original languageEnglish
JournalDiabetologia
DOIs
Publication statusPublished - 17 Jun 2014

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    Eny, K. M., Lutgers, H. L., Maynard, J., Klein, B. E. K., Lee, K. E., Atzmon, G., Monnier, V. M., van Vliet-Ostaptchouk, J. V., Graaff, R., van der Harst, P., Snieder, H., van der Klauw, M. M., Sell, D. R., Hosseini, S. M., Cleary, P. A., Braffett, B. H., Orchard, T. J., Lyons, T. J., Howard, K., ... LifeLines Cohort Study Group (2014). GWAS identifies an NAT2 acetylator status tag single nucleotide polymorphism to be a major locus for skin fluorescence. Diabetologia. https://doi.org/10.1007/s00125-014-3286-9