HDL composition and HDL antioxidant capacity in patients on regular haemodialysis

O. Hasselwander, Jane McEneny, D. McMaster, Damian Fogarty, D.P. Nicholls, Alexander Maxwell, Ian Young

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Recent evidence suggests that HDL can directly inhibit LDL oxidation, a key early stage in atherogenesis. Patients with chronic renal failure are at increased cardiovascular risk, have reduced HDL levels and altered HDL composition. We have therefore investigated whether compositional changes in HDL lead to decreased HDL antioxidant capacity in these patients. In comparison to control subject HDL, patient HDL contained less total cholesterol, cholesterol esters, phospholipids and alpha-tocopherol. LDL, HDL and LDL + HDL were standardised for protein and oxidised in the presence of Cu2+. The rate of propagation during HDL oxidation was reduced in the patient group (3.28 +/- 0.65 x 10(-5) vs. 4.60 +/- 0.97 x 10(-5) abs. U/min, P
Original languageEnglish
Pages (from-to)125-133
Number of pages9
JournalAtherosclerosis
Volume143
Issue number1
DOIs
Publication statusPublished - Mar 1999

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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