Health-related quality of life among breast cancer patients compared to cancer survivors and age-matched women in the general population in Vietnam

Tran Thu Ngan*, Vu Quynh Mai, Hoang Van Minh, Michael Donnelly, Ciaran O’Neill

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Purpose: This study compared the health-related quality of life (HRQoL) of breast cancer (BC) patients, survivors, and age-matched women from the general population in Vietnam to address the paucity of HRQoL research and contribute to the robust assessment of BC screening and care in Vietnam. 

Methods: The standardised EQ-5D-5L instrument was incorporated in an online survey and a hospital-based face-to-face survey, and together with data from the Vietnam EQ-5D-5L norms study. χ2 tests assessed EQ-5D health profile associations and a Tobit regression model investigated the association between overall health status (EQ-VAS/utility scores) and sociodemographic and clinical characteristics. 

Results: A total of 309 participants (107 patients undergoing treatment and 202 survivors who had completed treatment) provided usable responses. The dimensions that affected mostly the HRQoL of women with BC were pain/discomfort and anxiety/depression. Current patients and survivors differed significantly regarding HRQoL dimensions of mobility, self-care, usual activities, and anxiety/depression. Their health utilities were 0.74 and 0.84, respectively, compared with 0.91 for age-matched Vietnamese women in the general population (p < 0.001). Treatment status (survivor vs patient), younger age, higher monthly household income, and higher education levels were associated with higher health utility. 

Conclusions: The results point to unmet needs in mental health support and well-being and for attention to be given to the development of a biopsychosocial system of cancer diagnosis, treatment, and care. The results will also inform future assessments of the comparative value for money of interventions intended to impact on breast cancer in Vietnam.

Original languageEnglish
JournalQuality of Life Research
Early online date20 Sep 2021
Publication statusEarly online date - 20 Sep 2021

Bibliographical note

Funding Information:
The work reported in this paper was undertaken during TTN’s PhD studies which is funded by the Profs Murray-Yarnell PhD studentship from Faculty of Medicine and Health Sciences, Queen’s University Belfast (United Kingdom). The funder of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. Queen’s University Belfast was also the sponsor for open access fee of this paper.

Publisher Copyright:
© 2021, The Author(s).


  • HRQoL
  • Breast cancer
  • Health utility
  • Vietnam
  • EQ-5D-5L

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health


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