Health-related quality of life among breast cancer patients compared to cancer survivors and age-matched women in the general population in Vietnam

Tran Thu Ngan; Vu Quynh Mai; Hoang Van Minh; Michael Donnelly; Ciaran O’Neill

doi:10.1007/s11136-021-02997-w

Health-related quality of life among breast cancer patients compared to cancer survivors and age-matched women in the general population in Vietnam

Tran Thu Ngan^*, Vu Quynh Mai, Hoang Van Minh, Michael Donnelly, Ciaran O’Neill

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

11 Citations (Scopus)

94 Downloads (Pure)

Abstract

Purpose: This study compared the health-related quality of life (HRQoL) of breast cancer (BC) patients, survivors, and age-matched women from the general population in Vietnam to address the paucity of HRQoL research and contribute to the robust assessment of BC screening and care in Vietnam.

Methods: The standardised EQ-5D-5L instrument was incorporated in an online survey and a hospital-based face-to-face survey, and together with data from the Vietnam EQ-5D-5L norms study. χ² tests assessed EQ-5D health profile associations and a Tobit regression model investigated the association between overall health status (EQ-VAS/utility scores) and sociodemographic and clinical characteristics.

Results: A total of 309 participants (107 patients undergoing treatment and 202 survivors who had completed treatment) provided usable responses. The dimensions that affected mostly the HRQoL of women with BC were pain/discomfort and anxiety/depression. Current patients and survivors differed significantly regarding HRQoL dimensions of mobility, self-care, usual activities, and anxiety/depression. Their health utilities were 0.74 and 0.84, respectively, compared with 0.91 for age-matched Vietnamese women in the general population (p < 0.001). Treatment status (survivor vs patient), younger age, higher monthly household income, and higher education levels were associated with higher health utility.

Conclusions: The results point to unmet needs in mental health support and well-being and for attention to be given to the development of a biopsychosocial system of cancer diagnosis, treatment, and care. The results will also inform future assessments of the comparative value for money of interventions intended to impact on breast cancer in Vietnam.

Original language	English
Journal	Quality of Life Research
Early online date	20 Sept 2021
DOIs	https://doi.org/10.1007/s11136-021-02997-w
Publication status	Early online date - 20 Sept 2021

Bibliographical note

Funding Information:
The work reported in this paper was undertaken during TTN’s PhD studies which is funded by the Profs Murray-Yarnell PhD studentship from Faculty of Medicine and Health Sciences, Queen’s University Belfast (United Kingdom). The funder of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. Queen’s University Belfast was also the sponsor for open access fee of this paper.

Publisher Copyright:
© 2021, The Author(s).

Keywords

HRQoL
Breast cancer
Health utility
Vietnam
EQ-5D-5L

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s11136-021-02997-wLicence: CC BY

Health‑related quality of life among breast cancer patients compared to cancer survivors and age‑matched women in the general population in Vietnam
Copyright 2021 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 793 KBLicence: CC BY

Feasibility, acceptability, and cost-effectiveness of breast cancer screening in Vietnam
Tran, N. (Author), O'Neill, C. (Supervisor), Donnelly, M. (Supervisor) & Minh, H. V. (Supervisor), Jul 2022
Student thesis: Doctoral Thesis › Doctor of Philosophy

11 Citations
1 Article

Cost-effectiveness of clinical breast examination screening programme among HER2-positive breast cancer patients: a modelling study
Ngan, T. T., Browne, S., Goodwin, M., Van Minh, H., Donnelly, M. & O'Neill, C., Jan 2023, In: Breast Cancer. 30, 1, p. 68–76 9 p.
Research output: Contribution to journal › Article › peer-review

Open Access
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2 Citations (Scopus)

40 Downloads (Pure)

Cite this

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title = "Health-related quality of life among breast cancer patients compared to cancer survivors and age-matched women in the general population in Vietnam",

abstract = "Purpose: This study compared the health-related quality of life (HRQoL) of breast cancer (BC) patients, survivors, and age-matched women from the general population in Vietnam to address the paucity of HRQoL research and contribute to the robust assessment of BC screening and care in Vietnam. Methods: The standardised EQ-5D-5L instrument was incorporated in an online survey and a hospital-based face-to-face survey, and together with data from the Vietnam EQ-5D-5L norms study. χ2 tests assessed EQ-5D health profile associations and a Tobit regression model investigated the association between overall health status (EQ-VAS/utility scores) and sociodemographic and clinical characteristics. Results: A total of 309 participants (107 patients undergoing treatment and 202 survivors who had completed treatment) provided usable responses. The dimensions that affected mostly the HRQoL of women with BC were pain/discomfort and anxiety/depression. Current patients and survivors differed significantly regarding HRQoL dimensions of mobility, self-care, usual activities, and anxiety/depression. Their health utilities were 0.74 and 0.84, respectively, compared with 0.91 for age-matched Vietnamese women in the general population (p < 0.001). Treatment status (survivor vs patient), younger age, higher monthly household income, and higher education levels were associated with higher health utility. Conclusions: The results point to unmet needs in mental health support and well-being and for attention to be given to the development of a biopsychosocial system of cancer diagnosis, treatment, and care. The results will also inform future assessments of the comparative value for money of interventions intended to impact on breast cancer in Vietnam.",

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note = "Funding Information: The work reported in this paper was undertaken during TTN{\textquoteright}s PhD studies which is funded by the Profs Murray-Yarnell PhD studentship from Faculty of Medicine and Health Sciences, Queen{\textquoteright}s University Belfast (United Kingdom). The funder of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. Queen{\textquoteright}s University Belfast was also the sponsor for open access fee of this paper. Publisher Copyright: {\textcopyright} 2021, The Author(s).",

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AU - Van Minh, Hoang

AU - Donnelly, Michael

AU - O’Neill, Ciaran

N1 - Funding Information: The work reported in this paper was undertaken during TTN’s PhD studies which is funded by the Profs Murray-Yarnell PhD studentship from Faculty of Medicine and Health Sciences, Queen’s University Belfast (United Kingdom). The funder of the study had no role in study design, data collection, data analysis, data interpretation, or writing of the report. The corresponding author had full access to all the data in the study and had final responsibility for the decision to submit for publication. Queen’s University Belfast was also the sponsor for open access fee of this paper. Publisher Copyright: © 2021, The Author(s).

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Y1 - 2021/9/20

N2 - Purpose: This study compared the health-related quality of life (HRQoL) of breast cancer (BC) patients, survivors, and age-matched women from the general population in Vietnam to address the paucity of HRQoL research and contribute to the robust assessment of BC screening and care in Vietnam. Methods: The standardised EQ-5D-5L instrument was incorporated in an online survey and a hospital-based face-to-face survey, and together with data from the Vietnam EQ-5D-5L norms study. χ2 tests assessed EQ-5D health profile associations and a Tobit regression model investigated the association between overall health status (EQ-VAS/utility scores) and sociodemographic and clinical characteristics. Results: A total of 309 participants (107 patients undergoing treatment and 202 survivors who had completed treatment) provided usable responses. The dimensions that affected mostly the HRQoL of women with BC were pain/discomfort and anxiety/depression. Current patients and survivors differed significantly regarding HRQoL dimensions of mobility, self-care, usual activities, and anxiety/depression. Their health utilities were 0.74 and 0.84, respectively, compared with 0.91 for age-matched Vietnamese women in the general population (p < 0.001). Treatment status (survivor vs patient), younger age, higher monthly household income, and higher education levels were associated with higher health utility. Conclusions: The results point to unmet needs in mental health support and well-being and for attention to be given to the development of a biopsychosocial system of cancer diagnosis, treatment, and care. The results will also inform future assessments of the comparative value for money of interventions intended to impact on breast cancer in Vietnam.

AB - Purpose: This study compared the health-related quality of life (HRQoL) of breast cancer (BC) patients, survivors, and age-matched women from the general population in Vietnam to address the paucity of HRQoL research and contribute to the robust assessment of BC screening and care in Vietnam. Methods: The standardised EQ-5D-5L instrument was incorporated in an online survey and a hospital-based face-to-face survey, and together with data from the Vietnam EQ-5D-5L norms study. χ2 tests assessed EQ-5D health profile associations and a Tobit regression model investigated the association between overall health status (EQ-VAS/utility scores) and sociodemographic and clinical characteristics. Results: A total of 309 participants (107 patients undergoing treatment and 202 survivors who had completed treatment) provided usable responses. The dimensions that affected mostly the HRQoL of women with BC were pain/discomfort and anxiety/depression. Current patients and survivors differed significantly regarding HRQoL dimensions of mobility, self-care, usual activities, and anxiety/depression. Their health utilities were 0.74 and 0.84, respectively, compared with 0.91 for age-matched Vietnamese women in the general population (p < 0.001). Treatment status (survivor vs patient), younger age, higher monthly household income, and higher education levels were associated with higher health utility. Conclusions: The results point to unmet needs in mental health support and well-being and for attention to be given to the development of a biopsychosocial system of cancer diagnosis, treatment, and care. The results will also inform future assessments of the comparative value for money of interventions intended to impact on breast cancer in Vietnam.

KW - HRQoL

KW - Breast cancer

KW - Health utility

KW - Vietnam

KW - EQ-5D-5L

U2 - 10.1007/s11136-021-02997-w

DO - 10.1007/s11136-021-02997-w

M3 - Article

C2 - 34541610

SN - 0962-9343

JO - Quality of Life Research

JF - Quality of Life Research

ER -

Health-related quality of life among breast cancer patients compared to cancer survivors and age-matched women in the general population in Vietnam

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Fingerprint

Student theses

Feasibility, acceptability, and cost-effectiveness of breast cancer screening in Vietnam

Research output

Cost-effectiveness of clinical breast examination screening programme among HER2-positive breast cancer patients: a modelling study

Cite this