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Abstract
Hybrid iron oxide-gold nanoparticles (HNPs) have shown potential in cancer therapy as agents for tumour ablation
and thermal switches for targeted drug release. Heat generation occurs by exploitation of the surface plasmon
resonance of the gold coating, which usually occurs at the maximum UV absorption wavelength. However, lasers
at such wavelength are often expensive and highly specialised. Here, we report the heating and monitoring of heat
dissipation of HNPs suspended in agar phantoms using a relatively inexpensive Ng: YAG pulsed 1064 nm laser source.
The particles experience heating of up to 40°C with a total area of heat dissipation up to 132.73 mm2 from the 1 mm
diameter irradiation point after 60 seconds. This work reports the potential and possible drawbacks of these particles
for translation into cancer therapy based on our findings.
and thermal switches for targeted drug release. Heat generation occurs by exploitation of the surface plasmon
resonance of the gold coating, which usually occurs at the maximum UV absorption wavelength. However, lasers
at such wavelength are often expensive and highly specialised. Here, we report the heating and monitoring of heat
dissipation of HNPs suspended in agar phantoms using a relatively inexpensive Ng: YAG pulsed 1064 nm laser source.
The particles experience heating of up to 40°C with a total area of heat dissipation up to 132.73 mm2 from the 1 mm
diameter irradiation point after 60 seconds. This work reports the potential and possible drawbacks of these particles
for translation into cancer therapy based on our findings.
| Original language | English |
|---|---|
| Number of pages | 7 |
| Journal | Journal of Nanomedicine and Nanotechnology |
| Volume | 6 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 10 Nov 2015 |
| Externally published | Yes |
Keywords
- Hybrid nanoparticles; Surface plasmon resonance; Heat
Access to Document
- Heat Dissipation of Hybrid Iron Oxide-Gold Nanoparticles in an Agar Phantom
© 2015 Curtis A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Pharmaceutics (Journal)
Malekigorji, M. (Peer reviewer)
2018 → …Activity: Publication peer-review and editorial work types › Publication peer-review
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Keele University
Malekigorji, M. (Contributor) & Hoskins, C. (Contributor)
15 Aug 2016 → 23 Aug 2016Activity: Visiting an external institution types › Visiting an external academic institution