Hemopoietic chimerism following stem cell transplantation

Shaun R McCann, Mireille Crampe, Karen Molloy, Mark Lawler, Mark Lawler

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)


Hematopoietic chimerism is a measure of the number of donor and recipient cells in the host following stem cell transplantation (SCT). The type of conditioning therapy prior to SCT has a major impact on the chimeric status in the recipient. Different techniques of measurement have varying sensitivities. The use of polymerase chain reaction (PCR) of short tandem repeats (STR) using fluorescent amplification permits quantification using Genescan analysis. When SCT is used for malignant haematological disorders, measurement of chimeric status may indicate early relapse and in aplastic anemia graft rejection. Reduced intensity or T-cell depletion is associated with mixed haemopoietic chimerism. SCT for benign haematological disorders does not require complete donor chimerism for a successful outcome.

Original languageEnglish
Pages (from-to)55-61
Number of pages7
JournalTransfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis
Issue number1
Publication statusPublished - Feb 2005


  • Anemia, Aplastic
  • Female
  • Hematologic Diseases
  • Humans
  • Karyotyping
  • Leukemia
  • Male
  • Polymerase Chain Reaction
  • Sensitivity and Specificity
  • Stem Cell Transplantation
  • Tandem Repeat Sequences
  • Transplantation Chimera
  • Transplantation, Homologous
  • Treatment Outcome


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