Hepatitis C as a risk factor for carotid atherosclerosis - a systematic review

Olubunmi O Olubamwo, Ifeoma N Onyeka, Juhani Miettola, Jussi Kauhanen, Tomi-Pekka Tuomainen

Research output: Contribution to journalReview articlepeer-review

16 Citations (Scopus)

Abstract

BACKGROUND: Observational studies on the association of chronic hepatitis C with carotid atherosclerosis have yielded varying results. In addition, previous related systematic reviews were limited in synthesis. By more careful selection and further synthesis, we summarize current body of evidence on the relationship between chronic hepatitis C and carotid atherosclerosis.

METHODS: All published observational studies related to the topic identified by systematic searches of PubMed and Scopus were screened based on diagnosis of chronic hepatitis C and diagnosis and estimation of the risk of a carotid atherosclerosis-related outcome. Selected studies were subjected to quality assessment, and eligible studies were used in subsequent narrative and quantitative syntheses.

RESULTS: The initial search identified 190 unique publications, which were narrowed by preliminary review to 16 potentially relevant original articles. After quality assessment, seven studies were eligible and were used in narrative synthesis. Five studies assessed the risk of increased carotid intimal media thickening using B mode ultrasonography; five studies assessed the risk of carotid plaque formation using B mode ultrasonography. Five of these studies were used in subsequent meta-analysis. The risk of a person with chronic hepatitis C developing carotid intimal media thickening is about 4·03 times the risk of an uninfected person. The risk of a person with chronic hepatitis C developing carotid plaque is about 3·94 times the risk of an uninfected person.

CONCLUSION: Current evidence shows that hepatitis C virus (HCV) or factors associated with HCV infection can promote the occurrence and progression of carotid atherosclerosis.

Original languageEnglish
Pages (from-to)249-60
JournalClinical physiology and functional imaging
Volume36
Issue number4
Early online date26 Jan 2015
DOIs
Publication statusPublished - 20 Jun 2016
Externally publishedYes

Bibliographical note

© 2015 Scandinavian Society of Clinical Physiology and Nuclear Medicine. Published by John Wiley & Sons Ltd.

Keywords

  • Carotid Arteries/diagnostic imaging
  • Carotid Artery Diseases/diagnostic imaging
  • Carotid Intima-Media Thickness
  • Disease Progression
  • Hepatitis C, Chronic/complications
  • Humans
  • Observational Studies as Topic
  • Odds Ratio
  • Plaque, Atherosclerotic
  • Predictive Value of Tests
  • Prognosis
  • Risk Assessment
  • Risk Factors

Fingerprint Dive into the research topics of 'Hepatitis C as a risk factor for carotid atherosclerosis - a systematic review'. Together they form a unique fingerprint.

Cite this