Hepatitis C as a risk factor for carotid atherosclerosis - a systematic review

Olubunmi O Olubamwo; Ifeoma N Onyeka; Juhani Miettola; Jussi Kauhanen; Tomi-Pekka Tuomainen

doi:10.1111/cpf.12229

Hepatitis C as a risk factor for carotid atherosclerosis - a systematic review

Olubunmi O Olubamwo, Ifeoma N Onyeka, Juhani Miettola, Jussi Kauhanen, Tomi-Pekka Tuomainen

Research output: Contribution to journal › Review article › peer-review

21 Citations (Scopus)

Abstract

BACKGROUND: Observational studies on the association of chronic hepatitis C with carotid atherosclerosis have yielded varying results. In addition, previous related systematic reviews were limited in synthesis. By more careful selection and further synthesis, we summarize current body of evidence on the relationship between chronic hepatitis C and carotid atherosclerosis.

METHODS: All published observational studies related to the topic identified by systematic searches of PubMed and Scopus were screened based on diagnosis of chronic hepatitis C and diagnosis and estimation of the risk of a carotid atherosclerosis-related outcome. Selected studies were subjected to quality assessment, and eligible studies were used in subsequent narrative and quantitative syntheses.

RESULTS: The initial search identified 190 unique publications, which were narrowed by preliminary review to 16 potentially relevant original articles. After quality assessment, seven studies were eligible and were used in narrative synthesis. Five studies assessed the risk of increased carotid intimal media thickening using B mode ultrasonography; five studies assessed the risk of carotid plaque formation using B mode ultrasonography. Five of these studies were used in subsequent meta-analysis. The risk of a person with chronic hepatitis C developing carotid intimal media thickening is about 4·03 times the risk of an uninfected person. The risk of a person with chronic hepatitis C developing carotid plaque is about 3·94 times the risk of an uninfected person.

CONCLUSION: Current evidence shows that hepatitis C virus (HCV) or factors associated with HCV infection can promote the occurrence and progression of carotid atherosclerosis.

Original language	English
Pages (from-to)	249-60
Journal	Clinical physiology and functional imaging
Volume	36
Issue number	4
Early online date	26 Jan 2015
DOIs	https://doi.org/10.1111/cpf.12229
Publication status	Published - 20 Jun 2016
Externally published	Yes

Bibliographical note

Keywords

Carotid Arteries/diagnostic imaging
Carotid Artery Diseases/diagnostic imaging
Carotid Intima-Media Thickness
Disease Progression
Hepatitis C, Chronic/complications
Humans
Observational Studies as Topic
Odds Ratio
Plaque, Atherosclerotic
Predictive Value of Tests
Prognosis
Risk Assessment
Risk Factors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/cpf.12229Licence: Unspecified

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title = "Hepatitis C as a risk factor for carotid atherosclerosis - a systematic review",

abstract = "BACKGROUND: Observational studies on the association of chronic hepatitis C with carotid atherosclerosis have yielded varying results. In addition, previous related systematic reviews were limited in synthesis. By more careful selection and further synthesis, we summarize current body of evidence on the relationship between chronic hepatitis C and carotid atherosclerosis.METHODS: All published observational studies related to the topic identified by systematic searches of PubMed and Scopus were screened based on diagnosis of chronic hepatitis C and diagnosis and estimation of the risk of a carotid atherosclerosis-related outcome. Selected studies were subjected to quality assessment, and eligible studies were used in subsequent narrative and quantitative syntheses.RESULTS: The initial search identified 190 unique publications, which were narrowed by preliminary review to 16 potentially relevant original articles. After quality assessment, seven studies were eligible and were used in narrative synthesis. Five studies assessed the risk of increased carotid intimal media thickening using B mode ultrasonography; five studies assessed the risk of carotid plaque formation using B mode ultrasonography. Five of these studies were used in subsequent meta-analysis. The risk of a person with chronic hepatitis C developing carotid intimal media thickening is about 4·03 times the risk of an uninfected person. The risk of a person with chronic hepatitis C developing carotid plaque is about 3·94 times the risk of an uninfected person.CONCLUSION: Current evidence shows that hepatitis C virus (HCV) or factors associated with HCV infection can promote the occurrence and progression of carotid atherosclerosis.",

keywords = "Carotid Arteries/diagnostic imaging, Carotid Artery Diseases/diagnostic imaging, Carotid Intima-Media Thickness, Disease Progression, Hepatitis C, Chronic/complications, Humans, Observational Studies as Topic, Odds Ratio, Plaque, Atherosclerotic, Predictive Value of Tests, Prognosis, Risk Assessment, Risk Factors",

author = "Olubamwo, {Olubunmi O} and Onyeka, {Ifeoma N} and Juhani Miettola and Jussi Kauhanen and Tomi-Pekka Tuomainen",

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AU - Onyeka, Ifeoma N

AU - Miettola, Juhani

AU - Kauhanen, Jussi

AU - Tuomainen, Tomi-Pekka

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N2 - BACKGROUND: Observational studies on the association of chronic hepatitis C with carotid atherosclerosis have yielded varying results. In addition, previous related systematic reviews were limited in synthesis. By more careful selection and further synthesis, we summarize current body of evidence on the relationship between chronic hepatitis C and carotid atherosclerosis.METHODS: All published observational studies related to the topic identified by systematic searches of PubMed and Scopus were screened based on diagnosis of chronic hepatitis C and diagnosis and estimation of the risk of a carotid atherosclerosis-related outcome. Selected studies were subjected to quality assessment, and eligible studies were used in subsequent narrative and quantitative syntheses.RESULTS: The initial search identified 190 unique publications, which were narrowed by preliminary review to 16 potentially relevant original articles. After quality assessment, seven studies were eligible and were used in narrative synthesis. Five studies assessed the risk of increased carotid intimal media thickening using B mode ultrasonography; five studies assessed the risk of carotid plaque formation using B mode ultrasonography. Five of these studies were used in subsequent meta-analysis. The risk of a person with chronic hepatitis C developing carotid intimal media thickening is about 4·03 times the risk of an uninfected person. The risk of a person with chronic hepatitis C developing carotid plaque is about 3·94 times the risk of an uninfected person.CONCLUSION: Current evidence shows that hepatitis C virus (HCV) or factors associated with HCV infection can promote the occurrence and progression of carotid atherosclerosis.

AB - BACKGROUND: Observational studies on the association of chronic hepatitis C with carotid atherosclerosis have yielded varying results. In addition, previous related systematic reviews were limited in synthesis. By more careful selection and further synthesis, we summarize current body of evidence on the relationship between chronic hepatitis C and carotid atherosclerosis.METHODS: All published observational studies related to the topic identified by systematic searches of PubMed and Scopus were screened based on diagnosis of chronic hepatitis C and diagnosis and estimation of the risk of a carotid atherosclerosis-related outcome. Selected studies were subjected to quality assessment, and eligible studies were used in subsequent narrative and quantitative syntheses.RESULTS: The initial search identified 190 unique publications, which were narrowed by preliminary review to 16 potentially relevant original articles. After quality assessment, seven studies were eligible and were used in narrative synthesis. Five studies assessed the risk of increased carotid intimal media thickening using B mode ultrasonography; five studies assessed the risk of carotid plaque formation using B mode ultrasonography. Five of these studies were used in subsequent meta-analysis. The risk of a person with chronic hepatitis C developing carotid intimal media thickening is about 4·03 times the risk of an uninfected person. The risk of a person with chronic hepatitis C developing carotid plaque is about 3·94 times the risk of an uninfected person.CONCLUSION: Current evidence shows that hepatitis C virus (HCV) or factors associated with HCV infection can promote the occurrence and progression of carotid atherosclerosis.

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KW - Carotid Intima-Media Thickness

KW - Disease Progression

KW - Hepatitis C, Chronic/complications

KW - Humans

KW - Observational Studies as Topic

KW - Odds Ratio

KW - Plaque, Atherosclerotic

KW - Predictive Value of Tests

KW - Prognosis

KW - Risk Assessment

KW - Risk Factors

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DO - 10.1111/cpf.12229

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SN - 1475-0961

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JO - Clinical physiology and functional imaging

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ER -

Hepatitis C as a risk factor for carotid atherosclerosis - a systematic review

Abstract

Bibliographical note

Keywords

UN SDGs

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