Hepatitis of unknown aetiology in children – epidemiological overview of cases reported in Europe, 1 January to 16 June 2022

Adriana Romaní Vidal; Aisling Vaughan; Francesco Innocenti; Soledad Colombe; Lina Nerlander; Natalia Rachwal; Bruno Christian Ciancio; Aikaterini Mougkou; Carlos Carvalho; Enrique Delgado; Piers Mook; Géraldine de Muylder; Michael Peeters; Tencho Tenev; Elitsa Golkocheva-Markova; Veronika Vorobieva Solholm Jensen; Anders Koch; Julie Figoni; Cécile Brouard; Georgia Nikolopoulou; Anastasia Zisouli; Annemarie Broderick; Lital Goldberg; Rivka Rich; Lior Hecht Sagie; Maria Elena Tosti; Barbara Suligoi; Rosa Joosten; Roan Pijnacker; Ingvild Fjeldheim; Eli Heen; Małgorzata Stępień; Piotr Polański; Rui Tato Marinho; João Vieira Martins; Carmen Varela; Ana Avellón; Emmi Andersson; Marie Jansson Mörk; Sema Mandal; Conall Watson; Laura Coughlan; Meera Chand; Claire Neill; Declan T Bradley; Kathy Li; Maureen O’Leary; Neil McInnes; Christopher J Williams; Ardiana Gjini; Erika Duffell; Richard Pebody

doi:10.2807/1560-7917.ES.2022.27.31.2200483

Hepatitis of unknown aetiology in children – epidemiological overview of cases reported in Europe, 1 January to 16 June 2022

Adriana Romaní Vidal, Aisling Vaughan, Francesco Innocenti, Soledad Colombe, Lina Nerlander, Natalia Rachwal, Bruno Christian Ciancio, Aikaterini Mougkou, Carlos Carvalho, Enrique Delgado, Piers Mook, Géraldine de Muylder, Michael Peeters, Tencho Tenev, Elitsa Golkocheva-Markova, Veronika Vorobieva Solholm Jensen, Anders Koch, Julie Figoni, Cécile Brouard, Georgia NikolopoulouAnastasia Zisouli, Annemarie Broderick, Lital Goldberg, Rivka Rich, Lior Hecht Sagie, Maria Elena Tosti, Barbara Suligoi, Rosa Joosten, Roan Pijnacker, Ingvild Fjeldheim, Eli Heen, Małgorzata Stępień, Piotr Polański, Rui Tato Marinho, João Vieira Martins, Carmen Varela, Ana Avellón, Emmi Andersson, Marie Jansson Mörk, Sema Mandal, Conall Watson, Laura Coughlan, Meera Chand, Claire Neill, Declan T Bradley, Kathy Li, Maureen O’Leary, Neil McInnes, Christopher J Williams, Ardiana Gjini, Erika Duffell, Richard Pebody

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Abstract

Acute hepatitis refers to a rapid onset inflammation of the liver that can progress to acute liver failure with significant morbidity and mortality. It may affect previously healthy individuals and can be due to several infectious causes, hepatitis A, B and E virus, Epstein-Barr virus and cytomegalovirus being some of the more common, as well as non-infectious causes. In 30-49% of children with acute hepatitis progressing to liver failure, the disease aetiology remains unknown, although this high proportion may be due to the lack of exhaustive diagnostic testing carried out [1-3]. Severe acute hepatitis and acute liver failure of unknown aetiology are not under surveillance in most countries, thus defining a baseline disease incidence is challenging.

Original language	English
Journal	Eurosurveillance
Volume	27
Issue number	31
DOIs	https://doi.org/10.2807/1560-7917.ES.2022.27.31.2200483
Publication status	Published - 04 Aug 2022

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Hepatitis of unknown aetiology in children – epidemiological overview of cases reported in Europe, 1 January to 16 June 2022
Copyright 2022 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
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Romaní Vidal, A., Vaughan, A., Innocenti, F., Colombe, S., Nerlander, L., Rachwal, N., Ciancio, B. C., Mougkou, A., Carvalho, C., Delgado, E., Mook, P., de Muylder, G., Peeters, M., Tenev, T., Golkocheva-Markova, E., Vorobieva Solholm Jensen, V., Koch, A., Figoni, J., Brouard, C., ... Pebody, R. (2022). Hepatitis of unknown aetiology in children – epidemiological overview of cases reported in Europe, 1 January to 16 June 2022. Eurosurveillance, 27(31). https://doi.org/10.2807/1560-7917.ES.2022.27.31.2200483

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title = "Hepatitis of unknown aetiology in children – epidemiological overview of cases reported in Europe, 1 January to 16 June 2022",

abstract = "Acute hepatitis refers to a rapid onset inflammation of the liver that can progress to acute liver failure with significant morbidity and mortality. It may affect previously healthy individuals and can be due to several infectious causes, hepatitis A, B and E virus, Epstein-Barr virus and cytomegalovirus being some of the more common, as well as non-infectious causes. In 30-49% of children with acute hepatitis progressing to liver failure, the disease aetiology remains unknown, although this high proportion may be due to the lack of exhaustive diagnostic testing carried out [1-3]. Severe acute hepatitis and acute liver failure of unknown aetiology are not under surveillance in most countries, thus defining a baseline disease incidence is challenging.",

author = "{Roman{\'i} Vidal}, Adriana and Aisling Vaughan and Francesco Innocenti and Soledad Colombe and Lina Nerlander and Natalia Rachwal and Ciancio, {Bruno Christian} and Aikaterini Mougkou and Carlos Carvalho and Enrique Delgado and Piers Mook and {de Muylder}, G{\'e}raldine and Michael Peeters and Tencho Tenev and Elitsa Golkocheva-Markova and {Vorobieva Solholm Jensen}, Veronika and Anders Koch and Julie Figoni and C{\'e}cile Brouard and Georgia Nikolopoulou and Anastasia Zisouli and Annemarie Broderick and Lital Goldberg and Rivka Rich and {Hecht Sagie}, Lior and Tosti, {Maria Elena} and Barbara Suligoi and Rosa Joosten and Roan Pijnacker and Ingvild Fjeldheim and Eli Heen and Ma{\l}gorzata St{\c e}pie{\'n} and Piotr Pola{\'n}ski and {Tato Marinho}, Rui and {Vieira Martins}, Jo{\~a}o and Carmen Varela and Ana Avell{\'o}n and Emmi Andersson and {Jansson M{\"o}rk}, Marie and Sema Mandal and Conall Watson and Laura Coughlan and Meera Chand and Claire Neill and Bradley, {Declan T} and Kathy Li and Maureen O{\textquoteright}Leary and Neil McInnes and Williams, {Christopher J} and Ardiana Gjini and Erika Duffell and Richard Pebody",

year = "2022",

month = aug,

day = "4",

doi = "10.2807/1560-7917.ES.2022.27.31.2200483",

language = "English",

volume = "27",

journal = "Eurosurveillance",

issn = "1025-496X",

publisher = "European Centre for Disease Prevention and Control (ECDC)",

number = "31",

}

Romaní Vidal, A, Vaughan, A, Innocenti, F, Colombe, S, Nerlander, L, Rachwal, N, Ciancio, BC, Mougkou, A, Carvalho, C, Delgado, E, Mook, P, de Muylder, G, Peeters, M, Tenev, T, Golkocheva-Markova, E, Vorobieva Solholm Jensen, V, Koch, A, Figoni, J, Brouard, C, Nikolopoulou, G, Zisouli, A, Broderick, A, Goldberg, L, Rich, R, Hecht Sagie, L, Tosti, ME, Suligoi, B, Joosten, R, Pijnacker, R, Fjeldheim, I, Heen, E, Stępień, M, Polański, P, Tato Marinho, R, Vieira Martins, J, Varela, C, Avellón, A, Andersson, E, Jansson Mörk, M, Mandal, S, Watson, C, Coughlan, L, Chand, M, Neill, C, Bradley, DT, Li, K, O’Leary, M, McInnes, N, Williams, CJ, Gjini, A, Duffell, E & Pebody, R 2022, 'Hepatitis of unknown aetiology in children – epidemiological overview of cases reported in Europe, 1 January to 16 June 2022', Eurosurveillance, vol. 27, no. 31. https://doi.org/10.2807/1560-7917.ES.2022.27.31.2200483

TY - JOUR

T1 - Hepatitis of unknown aetiology in children – epidemiological overview of cases reported in Europe, 1 January to 16 June 2022

AU - Romaní Vidal, Adriana

AU - Vaughan, Aisling

AU - Innocenti, Francesco

AU - Colombe, Soledad

AU - Nerlander, Lina

AU - Rachwal, Natalia

AU - Ciancio, Bruno Christian

AU - Mougkou, Aikaterini

AU - Carvalho, Carlos

AU - Delgado, Enrique

AU - Mook, Piers

AU - de Muylder, Géraldine

AU - Peeters, Michael

AU - Tenev, Tencho

AU - Golkocheva-Markova, Elitsa

AU - Vorobieva Solholm Jensen, Veronika

AU - Koch, Anders

AU - Figoni, Julie

AU - Brouard, Cécile

AU - Nikolopoulou, Georgia

AU - Zisouli, Anastasia

AU - Broderick, Annemarie

AU - Goldberg, Lital

AU - Rich, Rivka

AU - Hecht Sagie, Lior

AU - Tosti, Maria Elena

AU - Suligoi, Barbara

AU - Joosten, Rosa

AU - Pijnacker, Roan

AU - Fjeldheim, Ingvild

AU - Heen, Eli

AU - Stępień, Małgorzata

AU - Polański, Piotr

AU - Tato Marinho, Rui

AU - Vieira Martins, João

AU - Varela, Carmen

AU - Avellón, Ana

AU - Andersson, Emmi

AU - Jansson Mörk, Marie

AU - Mandal, Sema

AU - Watson, Conall

AU - Coughlan, Laura

AU - Chand, Meera

AU - Neill, Claire

AU - Bradley, Declan T

AU - Li, Kathy

AU - O’Leary, Maureen

AU - McInnes, Neil

AU - Williams, Christopher J

AU - Gjini, Ardiana

AU - Duffell, Erika

AU - Pebody, Richard

PY - 2022/8/4

Y1 - 2022/8/4

N2 - Acute hepatitis refers to a rapid onset inflammation of the liver that can progress to acute liver failure with significant morbidity and mortality. It may affect previously healthy individuals and can be due to several infectious causes, hepatitis A, B and E virus, Epstein-Barr virus and cytomegalovirus being some of the more common, as well as non-infectious causes. In 30-49% of children with acute hepatitis progressing to liver failure, the disease aetiology remains unknown, although this high proportion may be due to the lack of exhaustive diagnostic testing carried out [1-3]. Severe acute hepatitis and acute liver failure of unknown aetiology are not under surveillance in most countries, thus defining a baseline disease incidence is challenging.

AB - Acute hepatitis refers to a rapid onset inflammation of the liver that can progress to acute liver failure with significant morbidity and mortality. It may affect previously healthy individuals and can be due to several infectious causes, hepatitis A, B and E virus, Epstein-Barr virus and cytomegalovirus being some of the more common, as well as non-infectious causes. In 30-49% of children with acute hepatitis progressing to liver failure, the disease aetiology remains unknown, although this high proportion may be due to the lack of exhaustive diagnostic testing carried out [1-3]. Severe acute hepatitis and acute liver failure of unknown aetiology are not under surveillance in most countries, thus defining a baseline disease incidence is challenging.

U2 - 10.2807/1560-7917.ES.2022.27.31.2200483

DO - 10.2807/1560-7917.ES.2022.27.31.2200483

M3 - Article

SN - 1025-496X

VL - 27

JO - Eurosurveillance

JF - Eurosurveillance

IS - 31

ER -

Hepatitis of unknown aetiology in children – epidemiological overview of cases reported in Europe, 1 January to 16 June 2022

Abstract

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