HER2: An emerging biomarker in non-breast and non-gastric cancers

Norhayati Omar, Benedict Yan, Manuel Salto-Tellez*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

20 Citations (Scopus)
6 Downloads (Pure)

Abstract

Introduction: HER2, a member of the human epidermal growth factor (HER) family of transmembrane tyrosine kinases, has been of considerable interest in oncology due to its significant role in the pathogenesis of various cancer types.

 Materials and methods: In this article, we review current data on HER2 as a potential biomarker in cancers other than breast and gastric by conducting an electronic database search using Pubmed. 

Results: The existing literature provides evidence that HER2 protein overexpression and genomic alterations exist in a subset of patients with non-breast and non-gastric cancers, and hints at the promise of anti-HER2 targeted therapy in these patients. 

Conclusion: Moving forward, the rigorous evaluation of HER2 (protein and genomic) status as a predictive biomarker will be necessary to bring anti-HER2 therapeutics for non-breast and non-gastric cancers to the clinic.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalPathogenesis
Volume2
Issue number3
Early online date06 Jun 2015
DOIs
Publication statusPublished - 01 Aug 2015

Bibliographical note

Publisher Copyright:
© 2015.

Keywords

  • Biomarker
  • HER2
  • Oncology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology
  • Cancer Research

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